无烟烟草使用与口腔癌风险:来自孟加拉国的一项基于医院的病例对照研究

IF 2.1 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Tobacco Use Insights Pub Date : 2025-10-03 eCollection Date: 2025-01-01 DOI:10.1177/1179173X251383752
Md Zahid Ullah, Jennifer Nw Lim, Marc Chrysanthou, Md Mostafizur Rahman, Md Saiful Arefin, Ashis Dhar, Md Sadat Hosen Shahriar
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引用次数: 0

摘要

目的:无烟烟草(SLT)的使用在南亚很常见,并且与口腔癌密切相关。在SLT使用广泛的孟加拉国,证据仍然有限。本研究调查了孟加拉国成年人使用SLT与口腔癌之间的关系,并估计了人口水平的负担。方法:这是孟加拉国第一个基于医院的病例对照研究,研究了SLT使用与口腔癌之间的关系。于2015年7月至12月在达卡进行。共招募了169名新诊断的口腔癌病例和338名频率匹配的对照组。结构化访谈收集了SLT使用、吸烟、饮酒、BMI和社会人口变量的数据。校正优势比(ORs)和95%置信区间(ci)使用无条件逻辑回归估计。根据国家SLT患病率计算人口归因分数(PAFs)。结果:SLT的使用与口腔癌密切相关(调整后OR: 8.78; 95% CI: 5.14-15.00)。女性的风险(OR: 14.33, 95% CI: 6.33-32.42)高于男性(OR: 5.29, 95% CI: 2.62-10.67)。男性SLT和吸烟双重使用者的风险最大(OR: 17.23, 95% CI: 5.70-52.01)。SLT类型分析显示,吸烟时使用槟榔液(BQ) (OR: 8.93, 95% CI: 5.23-15.27)和不吸烟时使用槟榔液(OR: 4.43, 95% CI: 1.94-10.10)与口腔癌有显著的独立关联。观察到剂量-反应关系,特别是在妇女中。据估计,在孟加拉国,使用SLT的男性和女性口腔癌病例分别占41%和76%。结论:SLT是孟加拉国口腔癌的一个主要的、可改变的危险因素,特别是在妇女和双重烟草使用者中。这些发现支持加强监管、性别敏感教育和有针对性的SLT控制策略的必要性。诸如此类的地方证据对于制定国家和国际口腔癌预防政策至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Smokeless Tobacco Usage and Oral Cancer Risk: A Hospital-Based Case-Control Study From Bangladesh.

Objectives: Smokeless tobacco (SLT) use is common in South Asia and strongly associated with oral cancer. In Bangladesh, where SLT use is widespread, evidence remains limited. This study examined the association between SLT use and oral cancer among Bangladeshi adults and estimated the population-level burden.

Methods: This first hospital-based case-control study from Bangladesh examined the association between SLT use and oral cancer. Conducted in Dhaka between July and December 2015. A total of 169 newly diagnosed oral cancer cases and 338 frequency-matched controls were recruited. Structured interviews collected data on SLT use, smoking, alcohol, BMI, and socio-demographic variables. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Population attributable fractions (PAFs) were calculated based on national SLT prevalence.

Results: SLT use was strongly associated with oral cancer (adjusted OR: 8.78; 95% CI: 5.14-15.00). Risk was higher in women (OR: 14.33, 95% CI: 6.33-32.42) than in men (OR: 5.29, 95% CI: 2.62-10.67). Male dual users of SLT and smoked tobacco had the greatest risk (OR: 17.23, 95% CI: 5.70-52.01). Analysis by SLT type indicated significant independent associations with oral cancer for both Betel Quid (BQ) usage with tobacco (OR: 8.93, 95% CI: 5.23-15.27) and without tobacco (OR: 4.43, 95% CI: 1.94-10.10). A dose-response relationship was observed, particularly in women. SLT use accounted for an estimated 41% of male and 76% of female oral cancer cases in Bangladesh.

Conclusion: SLT is a major, modifiable risk factor for oral cancer in Bangladesh, particularly among women and dual tobacco users. These findings support the need for stronger regulation, gender-sensitive education, and targeted SLT control strategies. Local evidence such as this is vital to shaping national and international oral cancer prevention policies.

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Tobacco Use Insights
Tobacco Use Insights PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
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