Luisa Prochazkova, Laura C Carvalho, Natasza Marrouch, Jorge Encantado, Pedro J Teixeira
{"title":"探讨微剂量对健康行为改变的影响。","authors":"Luisa Prochazkova, Laura C Carvalho, Natasza Marrouch, Jorge Encantado, Pedro J Teixeira","doi":"10.1016/j.neuropharm.2025.110688","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>While microdosing psychedelics is increasingly popular for enhancing well-being, its effects on health behavior change (HBC) remain poorly understood. This study investigated self-reported health-related behavior changes and putative underlying psychological mechanisms associated with psychedelic microdosing in a naturalistic setting.</p><p><strong>Methods: </strong>A retrospective mixed-method survey was conducted with 365 participants who had experience with psychedelic microdosing. Participants completed quantitative and qualitative items assessing changes in health behaviors (e.g., sleep, physical activity, diet) and psychological mechanisms (e.g., self-efficacy, emotional regulation) as a result of microdosing. Qualitative responses were analyzed thematically, and logistic regressions explored associations between behavioral change and individual/contextual predictors.</p><p><strong>Results: </strong>Microdosing was associated with positive changes across several health behaviors, most commonly in sleep, contemplative practices, physical activity, and work-life balance. Intention to change emerged as the strongest predictor of behavioral change, while dose, protocol, and psychiatric status were not significant predictors. Thematic analysis identified potential psychological mechanisms such as improved mental health, cognitive clarity, self-awareness, self-determination, and relatedness.</p><p><strong>Discussion: </strong>This study provides an initial exploration into the health-related behavior changes in microdosing. Future controlled studies should explore how microdosing might best support intentional health-promoting interventions.</p>","PeriodicalId":19139,"journal":{"name":"Neuropharmacology","volume":" ","pages":"110688"},"PeriodicalIF":4.6000,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the Effects of Microdosing on Health Behaviour Change.\",\"authors\":\"Luisa Prochazkova, Laura C Carvalho, Natasza Marrouch, Jorge Encantado, Pedro J Teixeira\",\"doi\":\"10.1016/j.neuropharm.2025.110688\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>While microdosing psychedelics is increasingly popular for enhancing well-being, its effects on health behavior change (HBC) remain poorly understood. This study investigated self-reported health-related behavior changes and putative underlying psychological mechanisms associated with psychedelic microdosing in a naturalistic setting.</p><p><strong>Methods: </strong>A retrospective mixed-method survey was conducted with 365 participants who had experience with psychedelic microdosing. Participants completed quantitative and qualitative items assessing changes in health behaviors (e.g., sleep, physical activity, diet) and psychological mechanisms (e.g., self-efficacy, emotional regulation) as a result of microdosing. Qualitative responses were analyzed thematically, and logistic regressions explored associations between behavioral change and individual/contextual predictors.</p><p><strong>Results: </strong>Microdosing was associated with positive changes across several health behaviors, most commonly in sleep, contemplative practices, physical activity, and work-life balance. Intention to change emerged as the strongest predictor of behavioral change, while dose, protocol, and psychiatric status were not significant predictors. Thematic analysis identified potential psychological mechanisms such as improved mental health, cognitive clarity, self-awareness, self-determination, and relatedness.</p><p><strong>Discussion: </strong>This study provides an initial exploration into the health-related behavior changes in microdosing. Future controlled studies should explore how microdosing might best support intentional health-promoting interventions.</p>\",\"PeriodicalId\":19139,\"journal\":{\"name\":\"Neuropharmacology\",\"volume\":\" \",\"pages\":\"110688\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-10-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuropharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.neuropharm.2025.110688\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuropharm.2025.110688","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Exploring the Effects of Microdosing on Health Behaviour Change.
Objective: While microdosing psychedelics is increasingly popular for enhancing well-being, its effects on health behavior change (HBC) remain poorly understood. This study investigated self-reported health-related behavior changes and putative underlying psychological mechanisms associated with psychedelic microdosing in a naturalistic setting.
Methods: A retrospective mixed-method survey was conducted with 365 participants who had experience with psychedelic microdosing. Participants completed quantitative and qualitative items assessing changes in health behaviors (e.g., sleep, physical activity, diet) and psychological mechanisms (e.g., self-efficacy, emotional regulation) as a result of microdosing. Qualitative responses were analyzed thematically, and logistic regressions explored associations between behavioral change and individual/contextual predictors.
Results: Microdosing was associated with positive changes across several health behaviors, most commonly in sleep, contemplative practices, physical activity, and work-life balance. Intention to change emerged as the strongest predictor of behavioral change, while dose, protocol, and psychiatric status were not significant predictors. Thematic analysis identified potential psychological mechanisms such as improved mental health, cognitive clarity, self-awareness, self-determination, and relatedness.
Discussion: This study provides an initial exploration into the health-related behavior changes in microdosing. Future controlled studies should explore how microdosing might best support intentional health-promoting interventions.
期刊介绍：
Neuropharmacology publishes high quality, original research and review articles within the discipline of neuroscience, especially articles with a neuropharmacological component. However, papers within any area of neuroscience will be considered. The journal does not usually accept clinical research, although preclinical neuropharmacological studies in humans may be considered. The journal only considers submissions in which the chemical structures and compositions of experimental agents are readily available in the literature or disclosed by the authors in the submitted manuscript. Only in exceptional circumstances will natural products be considered, and then only if the preparation is well defined by scientific means. Neuropharmacology publishes articles of any length (original research and reviews).
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