Alessia Raineri, Sonja Rueegg, Thomas Radtke, Susi Kriemler, Kyra Zens, Giuseppe Pantaleo, Craig Fenwick, Céline Pellaton, Milo A Puhan
{"title":"评估T细胞监测在儿童和青少年一般人群中的价值——来自Ciao Corona队列研究的见解。","authors":"Alessia Raineri, Sonja Rueegg, Thomas Radtke, Susi Kriemler, Kyra Zens, Giuseppe Pantaleo, Craig Fenwick, Céline Pellaton, Milo A Puhan","doi":"10.3389/ijph.2025.1608612","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Serological monitoring of SARS-CoV-2 antibodies in children and adolescents has been crucial for pandemic surveillance and response, while the role of T cell response monitoring remains uncertain. This study aimed to assess the potential of T cell response monitoring in children and adolescents during the COVID-19 pandemic.</p><p><strong>Methods: </strong>We compared antibody and T cell-mediated immune responses in a subpopulation (n = 109) of children and adolescents from the Ciao Corona cohort study. Participants were followed up over 6 months, from November/December 2021 to June/July 2022, during the Delta and Omicron waves in Switzerland.</p><p><strong>Results: </strong>Circulating, virus-specific T cell responses in children and adolescents were generally low and heterogeneous. T cell-mediated responses were not consistent with SARS-CoV-2 infection status, with responses detectable in some seronegative individuals and not detectable in a considerable number of seropositive participants.</p><p><strong>Conclusion: </strong>Circulating, virus-specific T cell responses to SARS-CoV-2 in children and adolescents from the general population offer limited additional insight. Monitoring humoral immunity is likely a more cost-effective approach and should be the primary focus of immunological surveillance in the general paediatric population.</p>","PeriodicalId":14322,"journal":{"name":"International Journal of Public Health","volume":"70 ","pages":"1608612"},"PeriodicalIF":2.4000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489368/pdf/","citationCount":"0","resultStr":"{\"title\":\"Assessing the Value of T cell Monitoring in the General Population of Children and Adolescents - Insights From the Ciao Corona Cohort Study.\",\"authors\":\"Alessia Raineri, Sonja Rueegg, Thomas Radtke, Susi Kriemler, Kyra Zens, Giuseppe Pantaleo, Craig Fenwick, Céline Pellaton, Milo A Puhan\",\"doi\":\"10.3389/ijph.2025.1608612\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Serological monitoring of SARS-CoV-2 antibodies in children and adolescents has been crucial for pandemic surveillance and response, while the role of T cell response monitoring remains uncertain. This study aimed to assess the potential of T cell response monitoring in children and adolescents during the COVID-19 pandemic.</p><p><strong>Methods: </strong>We compared antibody and T cell-mediated immune responses in a subpopulation (n = 109) of children and adolescents from the Ciao Corona cohort study. Participants were followed up over 6 months, from November/December 2021 to June/July 2022, during the Delta and Omicron waves in Switzerland.</p><p><strong>Results: </strong>Circulating, virus-specific T cell responses in children and adolescents were generally low and heterogeneous. T cell-mediated responses were not consistent with SARS-CoV-2 infection status, with responses detectable in some seronegative individuals and not detectable in a considerable number of seropositive participants.</p><p><strong>Conclusion: </strong>Circulating, virus-specific T cell responses to SARS-CoV-2 in children and adolescents from the general population offer limited additional insight. Monitoring humoral immunity is likely a more cost-effective approach and should be the primary focus of immunological surveillance in the general paediatric population.</p>\",\"PeriodicalId\":14322,\"journal\":{\"name\":\"International Journal of Public Health\",\"volume\":\"70 \",\"pages\":\"1608612\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489368/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Public Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/ijph.2025.1608612\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/ijph.2025.1608612","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Assessing the Value of T cell Monitoring in the General Population of Children and Adolescents - Insights From the Ciao Corona Cohort Study.
Objectives: Serological monitoring of SARS-CoV-2 antibodies in children and adolescents has been crucial for pandemic surveillance and response, while the role of T cell response monitoring remains uncertain. This study aimed to assess the potential of T cell response monitoring in children and adolescents during the COVID-19 pandemic.
Methods: We compared antibody and T cell-mediated immune responses in a subpopulation (n = 109) of children and adolescents from the Ciao Corona cohort study. Participants were followed up over 6 months, from November/December 2021 to June/July 2022, during the Delta and Omicron waves in Switzerland.
Results: Circulating, virus-specific T cell responses in children and adolescents were generally low and heterogeneous. T cell-mediated responses were not consistent with SARS-CoV-2 infection status, with responses detectable in some seronegative individuals and not detectable in a considerable number of seropositive participants.
Conclusion: Circulating, virus-specific T cell responses to SARS-CoV-2 in children and adolescents from the general population offer limited additional insight. Monitoring humoral immunity is likely a more cost-effective approach and should be the primary focus of immunological surveillance in the general paediatric population.
期刊介绍：
The International Journal of Public Health publishes scientific articles relevant to global public health, from different countries and cultures, and assembles them into issues that raise awareness and understanding of public health problems and solutions. The Journal welcomes submissions of original research, critical and relevant reviews, methodological papers and manuscripts that emphasize theoretical content. IJPH sometimes publishes commentaries and opinions. Special issues highlight key areas of current research. The Editorial Board''s mission is to provide a thoughtful forum for contemporary issues and challenges in global public health research and practice.
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