ft3 / ft4比值作为儿童Graves病筛查指标的应用

IF 1.2 Q4 ENDOCRINOLOGY & METABOLISM
Clinical Pediatric Endocrinology Pub Date : 2025-10-01 Epub Date: 2025-07-05 DOI:10.1297/cpe.2025-0022
Kazuhiro Shimura, Kentaro Sawano, Keisuke Nagasaki, Kiyomi Abe, Tomohiro Ishii, Tomonobu Hasegawa, Yukihiro Hasegawa
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引用次数: 0

摘要

Graves病(GD)是小儿甲状腺毒症最常见的病因;然而,将其与其他疾病区分开来是一项挑战。高游离三碘甲状腺原氨酸与游离甲状腺素比率(FT3/FT4)已被确定为成人GD的指标。在这项回顾性观察性研究中,我们旨在通过分析日本三家医院的105例1-18岁甲状腺毒症患者的病历,探讨FT3/FT4比率作为儿童GD筛查标志物的效用。参与者被分为GD组(TSH受体抗体> 2.0 IU/L,需要抗甲状腺药物至少6个月,n = 70)和非GD组(n = 35)。GD组FT3/FT4比值中位数(范围)明显高于非GD组(3.41 [1.90-5.22]vs. 2.92 [1.50-4.40], p < 0.05)。FT3/FT4比率的受试者工作特征曲线分析显示曲线下面积为0.693(95%可信区间[CI], 0.577-0.808)。在最佳临界值2.88时,FT3/FT4比值对GD筛查的敏感性为0.86 (95% CI: 0.80-0.91),特异性为0.51 (95% CI: 0.39-0.62)。这些发现提示FT3/FT4比值作为儿童GD筛查标志物的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Utility of the FT3-to-FT4 ratio as a screening marker for pediatric Graves' disease.

Utility of the FT3-to-FT4 ratio as a screening marker for pediatric Graves' disease.

Utility of the FT3-to-FT4 ratio as a screening marker for pediatric Graves' disease.

Utility of the FT3-to-FT4 ratio as a screening marker for pediatric Graves' disease.

Graves' disease (GD) is the most common cause of pediatric thyrotoxicosis; however, differentiating it from other conditions is challenging. A high free triiodothyronine-to-free thyroxine ratio (FT3/FT4) ratio has been established as an indicator of GD in adults. In this retrospective observational study, we aimed to investigate the utility of the FT3/FT4 ratio as a screening marker for pediatric GD by analyzing the medical records of 105 patients aged 1-18 years who presented with thyrotoxicosis at three hospitals in Japan. The participants were divided into a GD group (TSH receptor antibody > 2.0 IU/L and requiring antithyroid drug for at least six months; n = 70) and a non-GD group (n = 35). The median (range) of the FT3/FT4 ratio was significantly higher in the GD group than in the non-GD group (3.41 [1.90-5.22] vs. 2.92 [1.50-4.40]; p < 0.05). Receiver operating characteristic curve analysis of the FT3/FT4 ratio revealed an area under the curve of 0.693 (95% confidence interval [CI], 0.577-0.808). At the optimal cutoff value of 2.88, the FT3/FT4 ratio demonstrated a sensitivity of 0.86 (95% CI: 0.80-0.91) and a specificity of 0.51 (95% CI: 0.39-0.62) for GD screening. These findings suggest the usefulness of the FT3/FT4 ratio as a screening marker for pediatric GD.

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来源期刊
Clinical Pediatric Endocrinology
Clinical Pediatric Endocrinology ENDOCRINOLOGY & METABOLISM-
CiteScore
2.40
自引率
7.10%
发文量
34
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