中东的面肌痉挛:来自高容量三级护理中心的见解。

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Kiran Waqar, Florian Roser, Moncy Thomas, Yasmin Abdelmajed, Emma De Freitas, Shivam Om Mittal
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引用次数: 0

摘要

目的:通过分析患者人口统计学、临床特征、治疗模式和结果,提供中东地区第一个全面的面肌痉挛(HFS)区域概况。方法:回顾性分析2015年1月至2024年12月诊断为HFS的成人(≥18岁)。不完整的记录被排除在外。数据包括人口统计学、临床特征、影像学、治疗和结果。严重程度按5分李克特量表评定。结果:240例转诊患者中,174例符合纳入标准。女性占56 %(男女比1:1.29),平均发病年龄42 ± 14岁。左侧受累占主导(56.7% %)。原发性HFS占64.4 %,继发性HFS与面部疼痛相关(p )结论:阿联酋的首次研究提供了详细的HFS概况,证实了肉毒杆菌毒素和微血管减压的高疗效。口服治疗可能提供支持性、非侵入性的益处。观察到的发病年龄和病因的变化表明潜在的遗传和环境影响,强调需要在该地区进行前瞻性多中心研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hemifacial spasm in the Middle East: Insights from a high-volume tertiary care center.

Objective: To provide the first comprehensive regional profile of hemifacial spasm (HFS) in the Middle East by analyzing patient demographics, clinical features, treatment patterns, and outcomes.

Methods: We retrospectively reviewed adults (≥18 years) diagnosed with HFS from January 2015 to December 2024. Incomplete records were excluded. Data included demographics, clinical features, imaging, treatments, and outcomes. Severity was rated on a 5-point Likert scale. Chi-square tests determined statistical significance (p < 0.05).

Results: Of 240 referred patients, 174 met inclusion criteria. Females accounted for 56 % (male-to-female ratio 1:1.29), with mean age of onset 42 ± 14 years. Left-sided involvement predominated (56.7 %). Primary HFS comprised 64.4 % of cases, secondary HFS correlated with facial pain (p < 0.01) and weakness (p < 0.01). Hypertension showed no association with laterality (p = 0.27). Botulinum toxin injections yielded moderate-to-marked improvement in 92 % of patients, while microvascular decompression achieved sustained relief in 21 of 22 cases. Oral therapy provided modest benefit. Spontaneous remission occurred in 10 patients.

Conclusion: This first UAE study provides a detailed HFS profile, confirming high efficacy of botulinum toxin and microvascular decompression. Oral therapy may offer supportive, noninvasive benefit. Observed variations in onset age and etiology suggest potential genetic and environmental influences, highlighting the need for prospective multicenter studies in the region.

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来源期刊
Clinical Neurology and Neurosurgery
Clinical Neurology and Neurosurgery 医学-临床神经学
CiteScore
3.70
自引率
5.30%
发文量
358
审稿时长
46 days
期刊介绍: Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.
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