光催化1,3-炔与CO2的1,4-碳羧化反应。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-10-06 DOI:10.1021/acs.orglett.5c03750

Dong-Sen Duan, , , Fu Cheng, , , Li−Ru Chen, , , Ke-Yang Yu, , , Yu He, , , Chi Wang, , , Wen Bao, , , Dao-Yong Zhu*, , and , Shao-Hua Wang*,

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引用次数: 0

摘要

在此，我们报道了通过巯基介导的氢原子转移（HAT）和甲酸酯协同机制，1,3-炔与CO2的光催化区域选择性1,4-碳羧化反应。该策略使用甲酸和二氧化碳作为协同碳源，以提供各种芳基、杂芳基和烷基功能化的四取代烯羧酸。该反应显示出广泛的底物范围，包括电子和空间变化的炔和碘化物，并促进生物活性分子的后期功能化。克级合成和衍生化实验进一步证明了它的合成实用性。

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Photocatalytic 1,4-Carbocarboxylation of 1,3-Enynes with CO2

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Photocatalytic 1,4-Carbocarboxylation of 1,3-Enynes with CO2

Herein, we report a photocatalytic regioselective 1,4-carbocarboxylation of 1,3-enynes with CO₂ enabled by a thiol-mediated hydrogen atom transfer (HAT) and formate cooperative mechanism. This strategy uses formate and CO₂ as synergistic carbon sources, to deliver a diverse array of aryl-, heteroaryl-, and alkyl-functionalized tetrasubstituted allene carboxylic acids. The reaction exhibits broad substrate scope across electronically and sterically varied enynes and iodides, and facilitates late-stage functionalization of bioactive molecules. Gram-scale synthesis and derivatization experiments further demonstrate its synthetic utility.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.