染色体外DNA：肿瘤异质性的可靠途径

IF 33.3 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-10-06 DOI:10.1158/2159-8290.cd-25-1112

Emmanuel E. Korsah, Noah A. Dusseau, Eunhee Yi

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引用次数: 0

摘要

摘要：染色体外DNA （ecDNA）已被认为是基因组和转录水平上肿瘤异质性的关键因素，分别通过不平等分离和ecDNA中心形成。在这一期的《癌症发现》中，两项研究进一步扩展了我们对ecDNA在表型和时空水平上增强肿瘤异质性以及在肿瘤进化过程中提供强大选择优势方面的作用的理解。参见Montuori et al.，第2054页。参见Noorani et al.，第2078页

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Extrachromosomal DNA: A Trusted Path to Tumor Heterogeneity

Summary: Extrachromosomal DNA (ecDNA) has been suggested as a key factor of tumor heterogeneity at the genomic and transcriptional levels, via unequal segregation and ecDNA hub formation, respectively. In this issue of Cancer Discovery, two studies further expand our understanding of the roles of ecDNA in enhancing tumor heterogeneity at the phenotypic and spatiotemporal levels, as well as in providing a strong selective advantage during tumor evolution. See related article by Montuori et al., p. 2054 See related article by Noorani et al., p. 2078

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.