Ji Li, Ming Zhang, Juanjuan Song, Lina Zhang, Sheng-Guang Li
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Dual Malignancies in IgG4-Related Disease: A Diagnostic and Therapeutic Challenge.
We report a rare case of IgG4-related disease (IgG4-RD) presenting with retroperitoneal fibrosis and autoimmune pancreatitis, followed by sequential development of papillary thyroid carcinoma and diffuse large B cell lymphoma. Histopathologic and positron emission tomography-computed tomography findings were essential for diagnosis and guided timely treatment. This case highlights the potential oncogenic link between chronic IgG4-driven inflammation and B cell malignancy, emphasizing the need for vigilant cancer surveillance in patients with IgG4-RD.
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