Yusuff Adebayo Adebisi, Najim Z Alshahrani, Lucia Spicuzza, Francesco Pennisi, Giulio Geraci, Giulio Giacono Cantone, Venera Tomaselli, Riccardo Polosa
{"title":"当前纯电子烟使用者、当前纯卷烟使用者和从不使用任何一种产品的使用者之间呼吸性喘息的差异:一项基于人群的研究结果","authors":"Yusuff Adebayo Adebisi, Najim Z Alshahrani, Lucia Spicuzza, Francesco Pennisi, Giulio Geraci, Giulio Giacono Cantone, Venera Tomaselli, Riccardo Polosa","doi":"10.1186/s12954-025-01315-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>E-cigarettes have emerged as an alternative to combustible cigarettes, yet their comparative impact on respiratory symptoms remains uncertain. We investigated cross-sectional differences in self-reported wheezing between current exclusive e-cigarette users, current exclusive cigarette smokers, and never-users of either product.</p><p><strong>Methods: </strong>We analysed data from 9000 adults aged ≥ 16 years in the 2017-2019 Scottish Health Survey. The exposure was current nicotine use status (exclusive cigarette smoking, exclusive e-cigarette use, or never-use), and the outcome was self-reported wheezing in the past 12 months. Binary multivariable logistic regression estimated adjusted odds ratios (ORs) with 95% confidence intervals (CIs), controlling for age, sex, area-level socioeconomic deprivation, longstanding illness, doctor-diagnosed asthma and COPD, self-rated general health, alcohol consumption, age of smoking initiation, and exposure to second-hand smoke.</p><p><strong>Results: </strong>Compared to exclusive e-cigarette users, exclusive cigarette smokers had significantly higher odds of wheezing (adjusted OR = 1.80, 95% CI: 1.33-2.42, p < 0.001). Never-users had lower odds of wheezing than exclusive e-cigarette users, though the difference was not significant (adjusted OR = 0.66, 95% CI: 0.31-1.40, p = 0.275). Among exclusive cigarette smokers, the odds of wheezing increased with smoking intensity relative to exclusive e-cigarette users, indicating a dose-response relationship (χ² = 5.91, p = 0.018). Specifically, light smokers (< 10 cigarettes/day) had elevated but not significant odds (adjusted OR = 1.32, 95% CI: 0.92-1.89, p = 0.133), while moderate smokers (10-19 cigarettes/day) showed higher odds (adjusted OR = 1.85, 95% CI: 1.33-2.59, p < 0.001), and heavy smokers (≥ 20 cigarettes/day) had the greatest odds (adjusted OR = 2.27, 95% CI: 1.57-3.28, p < 0.001). Adjusted predicted probabilities of wheezing mirrored this pattern: compared with exclusive e-cigarette users, probabilities were significantly higher for moderate smokers (+ 7.2%, p = 0.002) and heavy smokers (+ 10.0%, p < 0.001), but not for light smokers (+ 3.0%, p = 0.152) or never-users (-3.9%, p = 0.306).</p><p><strong>Conclusions: </strong>Exclusive e-cigarette use was not associated with higher odds of wheezing compared with never-use, and it was linked to substantially lower odds than exclusive cigarette smoking. These findings suggest that, while complete abstinence remains the lowest-risk option, e-cigarette use may pose fewer respiratory symptoms than smoking, particularly for moderate-to-heavy smokers.</p>","PeriodicalId":12922,"journal":{"name":"Harm Reduction Journal","volume":"22 1","pages":"156"},"PeriodicalIF":4.0000,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495708/pdf/","citationCount":"0","resultStr":"{\"title\":\"Differences in respiratory wheezing between current exclusive e-cigarette users, current exclusive cigarette smokers, and never users of either product: findings from a population-based study.\",\"authors\":\"Yusuff Adebayo Adebisi, Najim Z Alshahrani, Lucia Spicuzza, Francesco Pennisi, Giulio Geraci, Giulio Giacono Cantone, Venera Tomaselli, Riccardo Polosa\",\"doi\":\"10.1186/s12954-025-01315-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>E-cigarettes have emerged as an alternative to combustible cigarettes, yet their comparative impact on respiratory symptoms remains uncertain. We investigated cross-sectional differences in self-reported wheezing between current exclusive e-cigarette users, current exclusive cigarette smokers, and never-users of either product.</p><p><strong>Methods: </strong>We analysed data from 9000 adults aged ≥ 16 years in the 2017-2019 Scottish Health Survey. The exposure was current nicotine use status (exclusive cigarette smoking, exclusive e-cigarette use, or never-use), and the outcome was self-reported wheezing in the past 12 months. Binary multivariable logistic regression estimated adjusted odds ratios (ORs) with 95% confidence intervals (CIs), controlling for age, sex, area-level socioeconomic deprivation, longstanding illness, doctor-diagnosed asthma and COPD, self-rated general health, alcohol consumption, age of smoking initiation, and exposure to second-hand smoke.</p><p><strong>Results: </strong>Compared to exclusive e-cigarette users, exclusive cigarette smokers had significantly higher odds of wheezing (adjusted OR = 1.80, 95% CI: 1.33-2.42, p < 0.001). Never-users had lower odds of wheezing than exclusive e-cigarette users, though the difference was not significant (adjusted OR = 0.66, 95% CI: 0.31-1.40, p = 0.275). Among exclusive cigarette smokers, the odds of wheezing increased with smoking intensity relative to exclusive e-cigarette users, indicating a dose-response relationship (χ² = 5.91, p = 0.018). Specifically, light smokers (< 10 cigarettes/day) had elevated but not significant odds (adjusted OR = 1.32, 95% CI: 0.92-1.89, p = 0.133), while moderate smokers (10-19 cigarettes/day) showed higher odds (adjusted OR = 1.85, 95% CI: 1.33-2.59, p < 0.001), and heavy smokers (≥ 20 cigarettes/day) had the greatest odds (adjusted OR = 2.27, 95% CI: 1.57-3.28, p < 0.001). Adjusted predicted probabilities of wheezing mirrored this pattern: compared with exclusive e-cigarette users, probabilities were significantly higher for moderate smokers (+ 7.2%, p = 0.002) and heavy smokers (+ 10.0%, p < 0.001), but not for light smokers (+ 3.0%, p = 0.152) or never-users (-3.9%, p = 0.306).</p><p><strong>Conclusions: </strong>Exclusive e-cigarette use was not associated with higher odds of wheezing compared with never-use, and it was linked to substantially lower odds than exclusive cigarette smoking. These findings suggest that, while complete abstinence remains the lowest-risk option, e-cigarette use may pose fewer respiratory symptoms than smoking, particularly for moderate-to-heavy smokers.</p>\",\"PeriodicalId\":12922,\"journal\":{\"name\":\"Harm Reduction Journal\",\"volume\":\"22 1\",\"pages\":\"156\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-10-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495708/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Harm Reduction Journal\",\"FirstCategoryId\":\"90\",\"ListUrlMain\":\"https://doi.org/10.1186/s12954-025-01315-8\",\"RegionNum\":2,\"RegionCategory\":\"社会学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SUBSTANCE ABUSE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Harm Reduction Journal","FirstCategoryId":"90","ListUrlMain":"https://doi.org/10.1186/s12954-025-01315-8","RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
Differences in respiratory wheezing between current exclusive e-cigarette users, current exclusive cigarette smokers, and never users of either product: findings from a population-based study.
Background: E-cigarettes have emerged as an alternative to combustible cigarettes, yet their comparative impact on respiratory symptoms remains uncertain. We investigated cross-sectional differences in self-reported wheezing between current exclusive e-cigarette users, current exclusive cigarette smokers, and never-users of either product.
Methods: We analysed data from 9000 adults aged ≥ 16 years in the 2017-2019 Scottish Health Survey. The exposure was current nicotine use status (exclusive cigarette smoking, exclusive e-cigarette use, or never-use), and the outcome was self-reported wheezing in the past 12 months. Binary multivariable logistic regression estimated adjusted odds ratios (ORs) with 95% confidence intervals (CIs), controlling for age, sex, area-level socioeconomic deprivation, longstanding illness, doctor-diagnosed asthma and COPD, self-rated general health, alcohol consumption, age of smoking initiation, and exposure to second-hand smoke.
Results: Compared to exclusive e-cigarette users, exclusive cigarette smokers had significantly higher odds of wheezing (adjusted OR = 1.80, 95% CI: 1.33-2.42, p < 0.001). Never-users had lower odds of wheezing than exclusive e-cigarette users, though the difference was not significant (adjusted OR = 0.66, 95% CI: 0.31-1.40, p = 0.275). Among exclusive cigarette smokers, the odds of wheezing increased with smoking intensity relative to exclusive e-cigarette users, indicating a dose-response relationship (χ² = 5.91, p = 0.018). Specifically, light smokers (< 10 cigarettes/day) had elevated but not significant odds (adjusted OR = 1.32, 95% CI: 0.92-1.89, p = 0.133), while moderate smokers (10-19 cigarettes/day) showed higher odds (adjusted OR = 1.85, 95% CI: 1.33-2.59, p < 0.001), and heavy smokers (≥ 20 cigarettes/day) had the greatest odds (adjusted OR = 2.27, 95% CI: 1.57-3.28, p < 0.001). Adjusted predicted probabilities of wheezing mirrored this pattern: compared with exclusive e-cigarette users, probabilities were significantly higher for moderate smokers (+ 7.2%, p = 0.002) and heavy smokers (+ 10.0%, p < 0.001), but not for light smokers (+ 3.0%, p = 0.152) or never-users (-3.9%, p = 0.306).
Conclusions: Exclusive e-cigarette use was not associated with higher odds of wheezing compared with never-use, and it was linked to substantially lower odds than exclusive cigarette smoking. These findings suggest that, while complete abstinence remains the lowest-risk option, e-cigarette use may pose fewer respiratory symptoms than smoking, particularly for moderate-to-heavy smokers.
期刊介绍:
Harm Reduction Journal is an Open Access, peer-reviewed, online journal whose focus is on the prevalent patterns of psychoactive drug use, the public policies meant to control them, and the search for effective methods of reducing the adverse medical, public health, and social consequences associated with both drugs and drug policies. We define "harm reduction" as "policies and programs which aim to reduce the health, social, and economic costs of legal and illegal psychoactive drug use without necessarily reducing drug consumption". We are especially interested in studies of the evolving patterns of drug use around the world, their implications for the spread of HIV/AIDS and other blood-borne pathogens.