Enrique Almanza-Aguilera, David Guananga-Álvarez, Yolanda Benavente, Alexandra Nieters, Caroline Besson, Fatemeh Saberi Hosnijeh, Cecilie Kyrø, Nicola P Bondonno, Christina C Dahm, Elisabete Weiderpass, Therese Truong, Mariem Louati-Hajji, Xuan Ren, Verena Katzke, Matthias B Schulze, Fabrizio Pasanisi, Claudia Vener, Giovanna Masala, Maria Teresa Giraudo, Rosario Tumino, Amaia Aizpurua, Maria-Jose Sánchez, José María Huerta, Marcela Guevara, Cristina Lasheras, Paolo Vineis, Roel Vermeulen, Raul Zamora-Ros, Delphine Casabonne
{"title":"摄入总、类别和亚类别（多）酚与淋巴样肿瘤的风险：EPIC队列的前瞻性分析","authors":"Enrique Almanza-Aguilera, David Guananga-Álvarez, Yolanda Benavente, Alexandra Nieters, Caroline Besson, Fatemeh Saberi Hosnijeh, Cecilie Kyrø, Nicola P Bondonno, Christina C Dahm, Elisabete Weiderpass, Therese Truong, Mariem Louati-Hajji, Xuan Ren, Verena Katzke, Matthias B Schulze, Fabrizio Pasanisi, Claudia Vener, Giovanna Masala, Maria Teresa Giraudo, Rosario Tumino, Amaia Aizpurua, Maria-Jose Sánchez, José María Huerta, Marcela Guevara, Cristina Lasheras, Paolo Vineis, Roel Vermeulen, Raul Zamora-Ros, Delphine Casabonne","doi":"10.1038/s41416-025-03228-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Existing epidemiological evidence regarding the potential role of (poly)phenol intake in lymphoma development is limited.</p><p><strong>Methods: </strong>We investigated the associations between the intake of total and individual classes and subclasses of (poly)phenols and the risk of lymphoma, including main frequent subtypes in the EPIC cohort using multivariable-adjusted Cox proportional hazards models.</p><p><strong>Results: </strong>During a mean 14-year follow-up (time frame: from 1990-1994 to 2008-2013), 2394 incident lymphoma cases were diagnosed from a total of 367,463 individuals. No significant associations were observed between total intakes of (poly)phenols, flavonoids, and phenolic acids and overall lymphoma risk. Total (poly)phenols, phenolic acid and hydroxycinnamic acid intakes were positively associated with Hodgkin lymphoma (HL) risk [HR<sub>log2</sub> = 2.56 (95% confidence interval: 1.27-5.16); 1.81 (1.14-2.87); and 1.48 (1.03-2.12), respectively]. Conversely, isoflavone intakes was inversely associated with risk of overall lymphoma [HR<sub>log2</sub> = 0.96 (0.93-0.99)], and non-Hodgkin lymphoma [HR<sub>log2</sub> = 0.95 (0.92-0.99)] and mature B-cell lymphoma [HR<sub>log2</sub> = 0.96 (0.92-0.99)], and flavone intakes with risk of multiple myeloma/plasma cell neoplasm [HR<sub>log2</sub> = 0.75 (0.60-0.95)].</p><p><strong>Conclusions: </strong>Our findings suggest that isoflavone intakes may reduce the risk of overall lymphoma and specific lymphoma subtypes, while phenolic acids, particularly hydroxycinnamic acids might increase the risk of HL.</p>","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intake of total, classes, and subclasses of (poly)phenols and risk of lymphoid neoplasms: a prospective analysis in the EPIC cohort.\",\"authors\":\"Enrique Almanza-Aguilera, David Guananga-Álvarez, Yolanda Benavente, Alexandra Nieters, Caroline Besson, Fatemeh Saberi Hosnijeh, Cecilie Kyrø, Nicola P Bondonno, Christina C Dahm, Elisabete Weiderpass, Therese Truong, Mariem Louati-Hajji, Xuan Ren, Verena Katzke, Matthias B Schulze, Fabrizio Pasanisi, Claudia Vener, Giovanna Masala, Maria Teresa Giraudo, Rosario Tumino, Amaia Aizpurua, Maria-Jose Sánchez, José María Huerta, Marcela Guevara, Cristina Lasheras, Paolo Vineis, Roel Vermeulen, Raul Zamora-Ros, Delphine Casabonne\",\"doi\":\"10.1038/s41416-025-03228-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Existing epidemiological evidence regarding the potential role of (poly)phenol intake in lymphoma development is limited.</p><p><strong>Methods: </strong>We investigated the associations between the intake of total and individual classes and subclasses of (poly)phenols and the risk of lymphoma, including main frequent subtypes in the EPIC cohort using multivariable-adjusted Cox proportional hazards models.</p><p><strong>Results: </strong>During a mean 14-year follow-up (time frame: from 1990-1994 to 2008-2013), 2394 incident lymphoma cases were diagnosed from a total of 367,463 individuals. No significant associations were observed between total intakes of (poly)phenols, flavonoids, and phenolic acids and overall lymphoma risk. Total (poly)phenols, phenolic acid and hydroxycinnamic acid intakes were positively associated with Hodgkin lymphoma (HL) risk [HR<sub>log2</sub> = 2.56 (95% confidence interval: 1.27-5.16); 1.81 (1.14-2.87); and 1.48 (1.03-2.12), respectively]. Conversely, isoflavone intakes was inversely associated with risk of overall lymphoma [HR<sub>log2</sub> = 0.96 (0.93-0.99)], and non-Hodgkin lymphoma [HR<sub>log2</sub> = 0.95 (0.92-0.99)] and mature B-cell lymphoma [HR<sub>log2</sub> = 0.96 (0.92-0.99)], and flavone intakes with risk of multiple myeloma/plasma cell neoplasm [HR<sub>log2</sub> = 0.75 (0.60-0.95)].</p><p><strong>Conclusions: </strong>Our findings suggest that isoflavone intakes may reduce the risk of overall lymphoma and specific lymphoma subtypes, while phenolic acids, particularly hydroxycinnamic acids might increase the risk of HL.</p>\",\"PeriodicalId\":9243,\"journal\":{\"name\":\"British Journal of Cancer\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":6.8000,\"publicationDate\":\"2025-10-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British Journal of Cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41416-025-03228-6\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Journal of Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41416-025-03228-6","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
Intake of total, classes, and subclasses of (poly)phenols and risk of lymphoid neoplasms: a prospective analysis in the EPIC cohort.
Background: Existing epidemiological evidence regarding the potential role of (poly)phenol intake in lymphoma development is limited.
Methods: We investigated the associations between the intake of total and individual classes and subclasses of (poly)phenols and the risk of lymphoma, including main frequent subtypes in the EPIC cohort using multivariable-adjusted Cox proportional hazards models.
Results: During a mean 14-year follow-up (time frame: from 1990-1994 to 2008-2013), 2394 incident lymphoma cases were diagnosed from a total of 367,463 individuals. No significant associations were observed between total intakes of (poly)phenols, flavonoids, and phenolic acids and overall lymphoma risk. Total (poly)phenols, phenolic acid and hydroxycinnamic acid intakes were positively associated with Hodgkin lymphoma (HL) risk [HRlog2 = 2.56 (95% confidence interval: 1.27-5.16); 1.81 (1.14-2.87); and 1.48 (1.03-2.12), respectively]. Conversely, isoflavone intakes was inversely associated with risk of overall lymphoma [HRlog2 = 0.96 (0.93-0.99)], and non-Hodgkin lymphoma [HRlog2 = 0.95 (0.92-0.99)] and mature B-cell lymphoma [HRlog2 = 0.96 (0.92-0.99)], and flavone intakes with risk of multiple myeloma/plasma cell neoplasm [HRlog2 = 0.75 (0.60-0.95)].
Conclusions: Our findings suggest that isoflavone intakes may reduce the risk of overall lymphoma and specific lymphoma subtypes, while phenolic acids, particularly hydroxycinnamic acids might increase the risk of HL.
期刊介绍：
The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.
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