质子泵抑制剂在预防奥沙利铂诱导的周围神经毒性中的一类作用

IF 2.9 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2025-09-29 DOI:10.1016/j.jphs.2025.09.010

Yusuke Mori , Keisuke Mine , Takehiro Kawashiri , Yusuke Koura , Mami Ueda , Risa Kaneko , Shunsuke Fujita , Akito Tsuruta , Satoru Koyanagi , Daisuke Kobayashi

{"title":"质子泵抑制剂在预防奥沙利铂诱导的周围神经毒性中的一类作用","authors":"Yusuke Mori , Keisuke Mine , Takehiro Kawashiri , Yusuke Koura , Mami Ueda , Risa Kaneko , Shunsuke Fujita , Akito Tsuruta , Satoru Koyanagi , Daisuke Kobayashi","doi":"10.1016/j.jphs.2025.09.010","DOIUrl":null,"url":null,"abstract":"<div><div>Oxaliplatin-induced peripheral neuropathy (OIPN) is a dose-limiting toxicity with limited countermeasures. Basic research has revealed that omeprazole, a proton pump inhibitor (PPI), exerts preventive effects against OIPN. In this study, we evaluated whether other PPIs exert similar effects via <em>in vitro</em> and <em>in vivo</em> experiments. Notably, esomeprazole, lansoprazole, and rabeprazole, classified as PPIs, prevented oxaliplatin-induced cultured F11 neuronal cell damage, and repeated PPI administration prevented mechanical allodynia in rats. However, vonoprazan, a potassium ion-competitive acid blocker, did not exert such effects. Overall, our results highlight the class effects of PPIs against OIPN.</div></div>","PeriodicalId":16786,"journal":{"name":"Journal of pharmacological sciences","volume":"159 4","pages":"Pages 279-282"},"PeriodicalIF":2.9000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Class effects of proton pump inhibitors in preventing oxaliplatin-induced peripheral neurotoxicity\",\"authors\":\"Yusuke Mori , Keisuke Mine , Takehiro Kawashiri , Yusuke Koura , Mami Ueda , Risa Kaneko , Shunsuke Fujita , Akito Tsuruta , Satoru Koyanagi , Daisuke Kobayashi\",\"doi\":\"10.1016/j.jphs.2025.09.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Oxaliplatin-induced peripheral neuropathy (OIPN) is a dose-limiting toxicity with limited countermeasures. Basic research has revealed that omeprazole, a proton pump inhibitor (PPI), exerts preventive effects against OIPN. In this study, we evaluated whether other PPIs exert similar effects via <em>in vitro</em> and <em>in vivo</em> experiments. Notably, esomeprazole, lansoprazole, and rabeprazole, classified as PPIs, prevented oxaliplatin-induced cultured F11 neuronal cell damage, and repeated PPI administration prevented mechanical allodynia in rats. However, vonoprazan, a potassium ion-competitive acid blocker, did not exert such effects. Overall, our results highlight the class effects of PPIs against OIPN.</div></div>\",\"PeriodicalId\":16786,\"journal\":{\"name\":\"Journal of pharmacological sciences\",\"volume\":\"159 4\",\"pages\":\"Pages 279-282\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of pharmacological sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1347861325000969\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacological sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1347861325000969","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

摘要

奥沙利铂诱导的周围神经病变（OIPN）是一种剂量限制性毒性，应对措施有限。基础研究表明，质子泵抑制剂奥美拉唑对OIPN具有预防作用。在这项研究中，我们通过体外和体内实验评估了其他PPIs是否具有类似的作用。值得注意的是，被归类为PPI的埃索美拉唑、兰索拉唑和雷贝拉唑可预防奥沙利铂诱导的培养F11神经元细胞损伤，反复给药可预防大鼠机械异常性疼痛。然而，vonoprazan，一种钾离子竞争酸阻滞剂，没有发挥这样的作用。总的来说，我们的结果强调了ppi对OIPN的类效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Class effects of proton pump inhibitors in preventing oxaliplatin-induced peripheral neurotoxicity

Oxaliplatin-induced peripheral neuropathy (OIPN) is a dose-limiting toxicity with limited countermeasures. Basic research has revealed that omeprazole, a proton pump inhibitor (PPI), exerts preventive effects against OIPN. In this study, we evaluated whether other PPIs exert similar effects via in vitro and in vivo experiments. Notably, esomeprazole, lansoprazole, and rabeprazole, classified as PPIs, prevented oxaliplatin-induced cultured F11 neuronal cell damage, and repeated PPI administration prevented mechanical allodynia in rats. However, vonoprazan, a potassium ion-competitive acid blocker, did not exert such effects. Overall, our results highlight the class effects of PPIs against OIPN.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.