Uniting Advanced Practice Nurses for Better Cancer Care: A Primer on Chimeric Antigen Receptor T-cell Therapy for Community-Based APNs

Chimeric antigen receptor (CAR) T-cell therapy represents a transformative approach in oncology and is increasingly being administered in outpatient settings. Community-based advanced practice nurses (APNs) play a vital role in ensuring safe and coordinated care during and after treatment. This article offers a practical primer for nononcology APNs that focuses on CAR T-cell therapy’s mechanisms, logistics, toxicities, and long-term considerations. Emphasizing early recognition, collaborative care, and patient education, the article aims to strengthen APNs’ confidence and competence in co-managing this high-risk population. As the landscape of cellular therapy evolves, equipping APNs with foundational knowledge is critical for enhancing survivorship and reducing preventable complications.