钙化性神经囊虫病患者认知功能障碍的频率和特点

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Marco Antonio Juan Vasquez-Baiocchi , Sofia Sanchez-Boluarte , S. Mathof Salas , Juan Galvez-Buccolini , Carolina Guzman , Kiran T. Thakur , Isidro Gonzales , Herberth Saavedra Pastor , Javier A. Bustos , Hector H. Garcia
{"title":"钙化性神经囊虫病患者认知功能障碍的频率和特点","authors":"Marco Antonio Juan Vasquez-Baiocchi ,&nbsp;Sofia Sanchez-Boluarte ,&nbsp;S. Mathof Salas ,&nbsp;Juan Galvez-Buccolini ,&nbsp;Carolina Guzman ,&nbsp;Kiran T. Thakur ,&nbsp;Isidro Gonzales ,&nbsp;Herberth Saavedra Pastor ,&nbsp;Javier A. Bustos ,&nbsp;Hector H. Garcia","doi":"10.1016/j.clineuro.2025.109181","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Neurocysticercosis (NCC) is the most common helminthic infection of the central nervous system (CNS). When NCC calcifies, it causes symptoms including memory impairment. Here we will assess the frequency and characteristics of cognitive impairment using screening tools in patients with calcified NCC.</div></div><div><h3>Methods</h3><div>We performed a cross-sectional study in participants of an ongoing cohort of patients with calcified NCC, who were administered the Mini-Mental State Examination (MMSE) and Memory Alteration Test (MAT) simultaneously. We analyzed these test scores in relation to sociodemographic, clinical, and neuroimaging characteristics.</div></div><div><h3>Results</h3><div>We included 336 individuals, with an average age of 43.6 ± 14.8 years, 56 % of whom were female. The median scores for MMSE and MAT were 27 (IQR 25–28) and 41 (IQR 36–45), respectively. We observed cognitive impairment in 43 (12.8 %) participants with MMSE and 90 (26.8 %) with MAT. Among the 57 participants aged 60 years and older, 17 (29.8 %) had cognitive impairment on MMSE and 29 (50.9 %) on MAT. Lower scores were associated with older age (p &lt; 0.001 for both tests), and the presence of left temporal lobe calcifications (p &lt; 0.001 for both), associations that persisted after multivariate adjustment (p = 0.017 for MMSE and p = 0.043 for MAT).</div></div><div><h3>Conclusion</h3><div>In this cohort, we found that low cognitive scores are frequently observed in patients with calcified NCC (12.8 % by MMSE, 26.8 % by MAT) and are associated with older age and calcifications in the left temporal lobe. Further studies with appropriate control groups are needed to assess these associations beyond screening tools and examine other contributing factors.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"258 ","pages":"Article 109181"},"PeriodicalIF":1.6000,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Frequency and characteristics of cognitive impairment in individuals with calcified neurocysticercosis\",\"authors\":\"Marco Antonio Juan Vasquez-Baiocchi ,&nbsp;Sofia Sanchez-Boluarte ,&nbsp;S. Mathof Salas ,&nbsp;Juan Galvez-Buccolini ,&nbsp;Carolina Guzman ,&nbsp;Kiran T. Thakur ,&nbsp;Isidro Gonzales ,&nbsp;Herberth Saavedra Pastor ,&nbsp;Javier A. Bustos ,&nbsp;Hector H. Garcia\",\"doi\":\"10.1016/j.clineuro.2025.109181\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Neurocysticercosis (NCC) is the most common helminthic infection of the central nervous system (CNS). When NCC calcifies, it causes symptoms including memory impairment. Here we will assess the frequency and characteristics of cognitive impairment using screening tools in patients with calcified NCC.</div></div><div><h3>Methods</h3><div>We performed a cross-sectional study in participants of an ongoing cohort of patients with calcified NCC, who were administered the Mini-Mental State Examination (MMSE) and Memory Alteration Test (MAT) simultaneously. We analyzed these test scores in relation to sociodemographic, clinical, and neuroimaging characteristics.</div></div><div><h3>Results</h3><div>We included 336 individuals, with an average age of 43.6 ± 14.8 years, 56 % of whom were female. The median scores for MMSE and MAT were 27 (IQR 25–28) and 41 (IQR 36–45), respectively. We observed cognitive impairment in 43 (12.8 %) participants with MMSE and 90 (26.8 %) with MAT. Among the 57 participants aged 60 years and older, 17 (29.8 %) had cognitive impairment on MMSE and 29 (50.9 %) on MAT. Lower scores were associated with older age (p &lt; 0.001 for both tests), and the presence of left temporal lobe calcifications (p &lt; 0.001 for both), associations that persisted after multivariate adjustment (p = 0.017 for MMSE and p = 0.043 for MAT).</div></div><div><h3>Conclusion</h3><div>In this cohort, we found that low cognitive scores are frequently observed in patients with calcified NCC (12.8 % by MMSE, 26.8 % by MAT) and are associated with older age and calcifications in the left temporal lobe. Further studies with appropriate control groups are needed to assess these associations beyond screening tools and examine other contributing factors.</div></div>\",\"PeriodicalId\":10385,\"journal\":{\"name\":\"Clinical Neurology and Neurosurgery\",\"volume\":\"258 \",\"pages\":\"Article 109181\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neurology and Neurosurgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0303846725004640\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurology and Neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0303846725004640","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的神经囊虫病(NCC)是最常见的中枢神经系统寄生虫感染。当NCC钙化时,它会引起包括记忆障碍在内的症状。在这里,我们将使用筛查工具评估钙化NCC患者认知功能障碍的频率和特征。方法:我们对钙化NCC患者进行了一项横断面研究,这些患者同时接受了迷你精神状态检查(MMSE)和记忆改变测试(MAT)。我们分析了这些测试分数与社会人口学、临床和神经影像学特征的关系。结果共纳入336例患者,平均年龄43.6 ±14.8岁,其中56 %为女性。MMSE和MAT的中位得分分别为27 (IQR 25-28)和41 (IQR 36-45)。我们观察到认知障碍在43个(12.8 %)参与者与MMSE和90(26.8 %)垫。57中参与者60岁以上,17(29.8 %)对患者认知障碍和29(50.9 %)垫。低分数与老年相关(p & lt; 0.001这两个测试都使用),左颞叶的存在钙化(两个p & lt; 0.001),协会,坚持多元校正后的显著(p = 0.017 MMSE和p = 0.043 垫)。在这个队列中,我们发现在钙化的NCC患者中经常观察到较低的认知评分(MMSE为12.8 %,MAT为26.8 %),并且与年龄和左颞叶钙化有关。需要对适当的对照组进行进一步的研究,以评估筛查工具之外的这些关联,并检查其他影响因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Frequency and characteristics of cognitive impairment in individuals with calcified neurocysticercosis

Objective

Neurocysticercosis (NCC) is the most common helminthic infection of the central nervous system (CNS). When NCC calcifies, it causes symptoms including memory impairment. Here we will assess the frequency and characteristics of cognitive impairment using screening tools in patients with calcified NCC.

Methods

We performed a cross-sectional study in participants of an ongoing cohort of patients with calcified NCC, who were administered the Mini-Mental State Examination (MMSE) and Memory Alteration Test (MAT) simultaneously. We analyzed these test scores in relation to sociodemographic, clinical, and neuroimaging characteristics.

Results

We included 336 individuals, with an average age of 43.6 ± 14.8 years, 56 % of whom were female. The median scores for MMSE and MAT were 27 (IQR 25–28) and 41 (IQR 36–45), respectively. We observed cognitive impairment in 43 (12.8 %) participants with MMSE and 90 (26.8 %) with MAT. Among the 57 participants aged 60 years and older, 17 (29.8 %) had cognitive impairment on MMSE and 29 (50.9 %) on MAT. Lower scores were associated with older age (p < 0.001 for both tests), and the presence of left temporal lobe calcifications (p < 0.001 for both), associations that persisted after multivariate adjustment (p = 0.017 for MMSE and p = 0.043 for MAT).

Conclusion

In this cohort, we found that low cognitive scores are frequently observed in patients with calcified NCC (12.8 % by MMSE, 26.8 % by MAT) and are associated with older age and calcifications in the left temporal lobe. Further studies with appropriate control groups are needed to assess these associations beyond screening tools and examine other contributing factors.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Clinical Neurology and Neurosurgery
Clinical Neurology and Neurosurgery 医学-临床神经学
CiteScore
3.70
自引率
5.30%
发文量
358
审稿时长
46 days
期刊介绍: Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信