基于脱细胞脂肪组织的复合水凝胶用于脂肪组织再生的进展和挑战:近十五年来的综述。

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2025-08-30 eCollection Date: 2025-01-01 DOI:10.7150/thno.120300
Lu Cui, Tian-Jie Lyu, Bin Fu, Yubo Wang, Qing Qu, Fanglin Wang, Rui Guo, Jun Fan
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引用次数: 0

摘要

利用脂肪组织作为调节全身代谢的动态内分泌器官的双重作用,脂肪组织再生已经成为解决创伤、肿瘤切除和烧伤引起的软组织缺损的一种变革性策略。脱细胞脂肪组织(DAT)支架由于其独特的保存了促脂肪形成和结构保存的细胞外基质(ECM)成分,在脂肪组织再生中具有重要的前景。然而,它们的临床转化面临瓶颈,包括压缩模量不足、不可预测的生物降解动力学和有限的新生血管能力。这篇综述批判性地综合了DAT处理的方法学进展,系统地评估了DAT保存与免疫原性残留消除的有效性,同时评估了它们作为植入材料的翻译潜力。在2013年以来DAT复合水凝胶工程方法论创新的基础上,本综述同时阐明了控制水凝胶功能的机械生物学调控范式,并评估了优化结构保真度的交联策略。关键的挑战和新兴领域也进行了讨论。目前材料性能指标的比较评估可能为进一步研究和翻译优化基于DAT的复合水凝胶用于软组织缺损修复提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances and challenges in decellularized adipose tissue based composite hydrogels for adipose tissue regeneration: a review over the last fifteen years.

Adipose tissue regeneration has emerged as a transformative strategy for addressing soft-tissue defects resulting from trauma, oncologic resection, and burn injuries, leveraging adipose tissue's dual role as a dynamic endocrine organ that regulates systemic metabolism. Decellularized adipose tissue (DAT) scaffolds hold significant promise in adipose tissue regeneration due to their unique preservation of pro-adipogenic and structurally preserved extracellular matrix (ECM) components. However, their clinical translation faces bottlenecks, including inadequate compressive modulus, unpredictable biodegradation kinetics and limited neovascularization capacity. This review critically synthesizes methodological advancements in DAT processing, systematically evaluating protocol efficacy in DAT preservation versus immunogenic residue elimination while assessing their translational potential as implant materials. Building upon methodological innovations in DAT composite hydrogel engineering since 2013, this overview concurrently elucidates mechanobiological regulation paradigms governing hydrogel functionality and evaluates crosslinking strategies that optimize structural fidelity. Critical challenges and emerging frontiers are also discussed. The current comparative assessment of material performance metrics may offer new insights for further investigation and translational optimization in DAT based composite hydrogels for repair of soft tissue defects.

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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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