Lu Cui, Tian-Jie Lyu, Bin Fu, Yubo Wang, Qing Qu, Fanglin Wang, Rui Guo, Jun Fan
{"title":"基于脱细胞脂肪组织的复合水凝胶用于脂肪组织再生的进展和挑战:近十五年来的综述。","authors":"Lu Cui, Tian-Jie Lyu, Bin Fu, Yubo Wang, Qing Qu, Fanglin Wang, Rui Guo, Jun Fan","doi":"10.7150/thno.120300","DOIUrl":null,"url":null,"abstract":"<p><p>Adipose tissue regeneration has emerged as a transformative strategy for addressing soft-tissue defects resulting from trauma, oncologic resection, and burn injuries, leveraging adipose tissue's dual role as a dynamic endocrine organ that regulates systemic metabolism. Decellularized adipose tissue (DAT) scaffolds hold significant promise in adipose tissue regeneration due to their unique preservation of pro-adipogenic and structurally preserved extracellular matrix (ECM) components. However, their clinical translation faces bottlenecks, including inadequate compressive modulus, unpredictable biodegradation kinetics and limited neovascularization capacity. This review critically synthesizes methodological advancements in DAT processing, systematically evaluating protocol efficacy in DAT preservation versus immunogenic residue elimination while assessing their translational potential as implant materials. Building upon methodological innovations in DAT composite hydrogel engineering since 2013, this overview concurrently elucidates mechanobiological regulation paradigms governing hydrogel functionality and evaluates crosslinking strategies that optimize structural fidelity. Critical challenges and emerging frontiers are also discussed. The current comparative assessment of material performance metrics may offer new insights for further investigation and translational optimization in DAT based composite hydrogels for repair of soft tissue defects.</p>","PeriodicalId":22932,"journal":{"name":"Theranostics","volume":"15 18","pages":"9508-9532"},"PeriodicalIF":13.3000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486143/pdf/","citationCount":"0","resultStr":"{\"title\":\"Advances and challenges in decellularized adipose tissue based composite hydrogels for adipose tissue regeneration: a review over the last fifteen years.\",\"authors\":\"Lu Cui, Tian-Jie Lyu, Bin Fu, Yubo Wang, Qing Qu, Fanglin Wang, Rui Guo, Jun Fan\",\"doi\":\"10.7150/thno.120300\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Adipose tissue regeneration has emerged as a transformative strategy for addressing soft-tissue defects resulting from trauma, oncologic resection, and burn injuries, leveraging adipose tissue's dual role as a dynamic endocrine organ that regulates systemic metabolism. Decellularized adipose tissue (DAT) scaffolds hold significant promise in adipose tissue regeneration due to their unique preservation of pro-adipogenic and structurally preserved extracellular matrix (ECM) components. However, their clinical translation faces bottlenecks, including inadequate compressive modulus, unpredictable biodegradation kinetics and limited neovascularization capacity. This review critically synthesizes methodological advancements in DAT processing, systematically evaluating protocol efficacy in DAT preservation versus immunogenic residue elimination while assessing their translational potential as implant materials. Building upon methodological innovations in DAT composite hydrogel engineering since 2013, this overview concurrently elucidates mechanobiological regulation paradigms governing hydrogel functionality and evaluates crosslinking strategies that optimize structural fidelity. Critical challenges and emerging frontiers are also discussed. The current comparative assessment of material performance metrics may offer new insights for further investigation and translational optimization in DAT based composite hydrogels for repair of soft tissue defects.</p>\",\"PeriodicalId\":22932,\"journal\":{\"name\":\"Theranostics\",\"volume\":\"15 18\",\"pages\":\"9508-9532\"},\"PeriodicalIF\":13.3000,\"publicationDate\":\"2025-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486143/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Theranostics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7150/thno.120300\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Theranostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7150/thno.120300","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Advances and challenges in decellularized adipose tissue based composite hydrogels for adipose tissue regeneration: a review over the last fifteen years.
Adipose tissue regeneration has emerged as a transformative strategy for addressing soft-tissue defects resulting from trauma, oncologic resection, and burn injuries, leveraging adipose tissue's dual role as a dynamic endocrine organ that regulates systemic metabolism. Decellularized adipose tissue (DAT) scaffolds hold significant promise in adipose tissue regeneration due to their unique preservation of pro-adipogenic and structurally preserved extracellular matrix (ECM) components. However, their clinical translation faces bottlenecks, including inadequate compressive modulus, unpredictable biodegradation kinetics and limited neovascularization capacity. This review critically synthesizes methodological advancements in DAT processing, systematically evaluating protocol efficacy in DAT preservation versus immunogenic residue elimination while assessing their translational potential as implant materials. Building upon methodological innovations in DAT composite hydrogel engineering since 2013, this overview concurrently elucidates mechanobiological regulation paradigms governing hydrogel functionality and evaluates crosslinking strategies that optimize structural fidelity. Critical challenges and emerging frontiers are also discussed. The current comparative assessment of material performance metrics may offer new insights for further investigation and translational optimization in DAT based composite hydrogels for repair of soft tissue defects.
期刊介绍:
Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.