肿瘤细胞命运的合成重编程以调节放射治疗诱导的动态反应:放射增敏和免疫调节作用的观点。

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2025-08-30 eCollection Date: 2025-01-01 DOI:10.7150/thno.119822
Wei Zhou, Lulu Wang, Hui Zhang, Yongzhong Wu, Menghuan Li, Zhong Luo
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引用次数: 0

摘要

放射治疗是临床上最常用的抗癌方式之一,它被广泛认为是一种有效和安全的治疗广泛的实体瘤适应症。有趣的是,越来越多的证据表明,肿瘤可以动态调节电离辐射(IR)暴露后的细胞命运决定,这有利于逃避辐射诱导的抗肿瘤细胞损伤和免疫刺激影响。因此,细胞命运决定的调控网络可能是增强肿瘤细胞对各种放射治疗方式易感性的一个有希望的靶点。在这篇综述中,我们提供了一个全面的机制,放射后的细胞命运控制肿瘤细胞逃避程序性细胞死亡(PCD),包括凋亡,坏死,焦亡和铁亡,而特别强调的是开发合成药物的治疗性调节放射后肿瘤细胞命运决定,以促进肿瘤细胞根除。重点关注它们在放大rt诱导的直接肿瘤细胞损伤以及促进ir后抗肿瘤免疫方面的治疗效用。我们设想这些合成细胞命运调控技术可以为提高放射治疗疗效提供新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthetic reprogramming of tumor cell fate for modulating radiotherapy-induced dynamic responses: perspectives on radiosensitizing and immunoregulatory effects.

Radiotherapy is one of the most commonly prescribed anticancer modalities in the clinic, which is widely recognized as an effective and safe treatment for a broad spectrum of solid tumor indications. Interestingly, there is increasing evidence that the tumors can dynamically modulate cell fate decisions after ionizing radiation (IR) exposure, which is beneficial for escaping the radiation-induced antitumorigenic cell damaging and immunostimulatory impacts. Consequently, the regulatory network of cell fate determination could be a promising target for enhancing the susceptibility of tumor cells to various radiotherapeutic modalities. In this review, we provide a comprehensive account on the mechanisms of post-radiation cell fate control in tumor cells to escape programmed cell death (PCD) including apoptosis, necrosis, pyroptosis and ferroptosis, while special emphasis is placed on the development of synthetic agents for the therapeutic modulation of post-radiation tumor cell fate decisions to facilitate tumor cell eradication, focusing on their therapeutic utility for amplifying the RT-induced direct tumor cell damage as well as promoting the post-IR antitumor immunity. We envision that these synthetic cell fate regulatory technologies could provide new avenues for improving radiotherapeutic efficacy.

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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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