血浆凝血因子viii和ix水平与心血管疾病和死亡率之间的关系：系统回顾和荟萃分析

IF 5 2区医学 Q1 HEMATOLOGY

Journal of Thrombosis and Haemostasis Pub Date : 2025-09-30 DOI:10.1016/j.jtha.2025.09.008

Katie Harris, Mark Woodward, Aaron R Folsom, Pamela L Lutsey, Ethan Cannon, Neil A Zakai, Mary Cushman, Nels C Olson, Nithya Kannan, Ryan Packer, Katherine Wilkinson, S Goya Wannamethee, Christopher C Patterson, Yoav Ben-Shlomo, Gordon D O Lowe

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引用次数: 0

摘要

背景：血浆凝血因子VIII （FVIII）和IX （FIX）水平与心血管疾病（CVD）和死亡率的关系尚不确定。目的：在一项普通人群前瞻性研究的荟萃分析中阐明FVIII和FIX与CVD和死亡率的关系。方法：我们对PubMed和Cochrane数据库进行了系统的文献综述，截至2024年7月19日，报告了血浆FVIII或FIX水平与心血管疾病发生风险的关联估计（和变异性测量）。对年龄、性别、收缩压、总胆固醇、吸烟和糖尿病等因素进行调整后的合并风险比（rr），在随机效应荟萃分析中评估FVIII和FIX水平对CVD事件、CVD和总死亡率的影响。结果：在FVIII的7项研究（32123名受试者中8888例）和FIX的4项研究（6951名受试者中2273例）中，每升高1 SD发生CVD的合并rr（95%置信区间）分别为1.12（1.09,1.14）和1.05（1.00,1.12）。FVIII的相应CVD死亡率和总死亡率rr分别为1.17（1.07,1.28）和1.16 (1.12,1.19)，FIX的相应CVD死亡率rr分别为1.14（1.06,1.22）和1.13（1.07,1.18）。比较90百分位以上和低于90百分位的因素水平，FVIII的合并rr为1.34 (1.25,1.44)；和1.02（0.85,1.22）。结论：在FVIII水平较高的人群分布中，CVD风险、CVD死亡率和总死亡率增加。心血管疾病死亡率和总死亡率的风险在FIX水平上也有所增加，但没有证据表明心血管疾病事件风险有独立的影响。

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ASSOCIATIONS BETWEEN PLASMA LEVELS OF COAGULATION FACTORS VIII AND IX AND INCIDENT CARDIOVASCULAR DISEASE AND MORTALITY: SYSTEMATIC REVIEW AND META-ANALYSIS.

Background: Associations of plasma levels of coagulation factors VIII (FVIII) and IX (FIX) with incident cardiovascular disease (CVD) and mortality remain uncertain.

Objective: To clarify associations of FVIII and FIX with CVD and mortality in a meta-analysis in general population prospective studies.

Methods: We conducted a systematic literature review up to 19 July 2024, of PubMed and Cochrane databases, reporting estimates (and measures of variability) of associations of plasma levels of FVIII or FIX with risks of incident CVD. Pooled risk ratios (RRs), adjusted for age, sex, systolic blood pressure, total cholesterol, smoking and diabetes, were estimated in a random effects meta-analysis for effects of FVIII and FIX levels on incident CVD, and CVD and total mortality.

Results: In 7 studies (8888 cases in 32,123 participants) for FVIII and 4 studies (2273 cases in 6951 participants) for FIX the pooled RRs (95% confidence interval) for incident CVD per 1 SD higher were 1.12 (1.09, 1.14) and 1.05 (1.00, 1.12), respectively. Corresponding CVD mortality and total mortality RRs for FVIII were 1.17 (1.07, 1.28) and 1.16 (1.12, 1.19), and for FIX;1.14 (1.06, 1.22) and 1.13 (1.07, 1.18), respectively. Comparing factor levels above versus below the 90th percentile, pooled RRs were 1.34 (1.25, 1.44) for FVIII; and 1.02 (0.85, 1.22) for FIX.

Conclusions: Risks of CVD, CVD mortality and total mortality increase across higher population distributions of FVIII levels. Risks of CVD mortality and total mortality also increase across FIX levels, but no evidence of an independent effect for incident CVD risk.

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来源期刊

Journal of Thrombosis and Haemostasis 医学-外周血管病

CiteScore

24.30

自引率

3.80%

发文量

321

审稿时长

1 months

期刊介绍： The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.