手足口病无症状和有症状患者肠道微生物多样性及其相关性评估

IF 3 2区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genomics Pub Date : 2025-09-30 DOI:10.1016/j.ygeno.2025.111126

Hongwei Jin , Bin Feng , Wenxiao Gong, Xiaoliang Chen, Dongli Wang, Yan Li, Weijun Huang, Wenting Peng

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引用次数: 0

摘要

•随着“宏基因组学”概念的提出和测序技术的发展，16S rRNA基因图谱在微生物多样性调查中得到了广泛的应用。本研究探讨了儿童手足口病（HFMD）的肠道微生物群。本研究采用16S rRNA测序技术，对24例无症状和有症状手足口病（手足口病）患儿和19例健康对照者的肠道菌群进行了研究。无症状和有症状手足口病患者的肠道微生物群与对照组不同，手足口病患者肠道微生物群的组成具有显著差异。手足口病患者的肠道菌群失调包括产生丁酸盐的细菌减少和诱导炎症的细菌上调。这些可能破坏了肠道生物粘膜屏障和宿主免疫功能，促进了肠道病毒的入侵。

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Evaluation of gut microbial diversity and correlation in asymptomatic and symptomatic patients with hand, foot and mouth disease

•
With the proposal of the concept of “metagenomics” and the development of sequencing technology, 16S rRNA gene profiling has been widely applied in the survey of microbial diversity. This study explored the gut microbiota of children with hand, foot and mouth disease (HFMD). This study investigated the gut microbiota of 24 children with asymptomatic and symptomatic hand, foot, and mouth disease (HFMD) and 19 healthy controls using 16S rRNA sequencing. The gut microbiota, both in asymptomatic and symptomatic HFMD patients, was distinct from the controls, with the composition of gut microbiota in the HFMD cases represented a significant difference. The dysbiosis of gut microbiota of the HFMD cases included a reduction of butyrate-producing bacteria and an up-regulation of inflammation-inducing bacteria. These may have impaired the intestinal biological mucosal barrier and host immune functions, promoting the invasion of the enterovirus.

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来源期刊

Genomics 生物-生物工程与应用微生物

CiteScore

9.60

自引率

2.30%

发文量

260

审稿时长

60 days

期刊介绍： Genomics is a forum for describing the development of genome-scale technologies and their application to all areas of biological investigation. As a journal that has evolved with the field that carries its name, Genomics focuses on the development and application of cutting-edge methods, addressing fundamental questions with potential interest to a wide audience. Our aim is to publish the highest quality research and to provide authors with rapid, fair and accurate review and publication of manuscripts falling within our scope.