Jiaxin Wan , Lin Liu , Haoran Wang , Liangwei Li , Wei Li , Shuheng Kou , Runtian Li , Jiayi Tang , Juanxiu Liu , Jing Zhang , Xiaohui Du , Ruqian Hao
{"title":"UNSX-HRNet:模拟全髋关节置换术中地标检测的解剖不确定性。","authors":"Jiaxin Wan , Lin Liu , Haoran Wang , Liangwei Li , Wei Li , Shuheng Kou , Runtian Li , Jiayi Tang , Juanxiu Liu , Jing Zhang , Xiaohui Du , Ruqian Hao","doi":"10.1016/j.compbiomed.2025.111146","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Accurate detection of anatomical landmarks from radiographic images is critical for total hip arthroplasty (THA) surgical planning and postoperative evaluation. However, existing methods face significant challenges in unstructured data, such as irregular patient postures or occluded landmarks, which hinder their robustness and reliability. This study aims to develop an advanced deep learning framework to address these challenges, by leveraging uncertainty estimation to handle unstructured data and assigning uncertainty scores to predicted landmarks, thereby alerting clinicians to focus on these results.</div></div><div><h3>Methods</h3><div>We propose Unstructured X-ray - High-Resolution Net (UNSX-HRNet), a framework that integrates high-resolution networks with uncertainty estimation based on anatomical relationships to predict landmarks without relying on a fixed number of points. The method suppresses low-certainty landmarks to accurately handle unstructured data while highlighting the certainty level of each landmark to provide correction guidance. The model was trained and tested on both structured and unstructured datasets, with performance evaluated using multiple precision metrics.</div></div><div><h3>Results</h3><div>Experimental results demonstrate that UNSX-HRNet achieves improvement, exceeding 60 % across multiple evaluation metrics when applied to unstructured datasets. On structured datasets, the framework maintains high performance, showcasing its robustness and adaptability across varying data conditions.</div></div><div><h3>Conclusions</h3><div>UNSX-HRNet offers a reliable and automated solution for THA landmark detection, addressing the challenges of unstructured data through uncertainty-aware predictions. This approach not only improves accuracy but also provides actionable insights for clinicians, contributing to the development of AI-driven expert systems for surgical planning and monitoring.</div></div>","PeriodicalId":10578,"journal":{"name":"Computers in biology and medicine","volume":"198 ","pages":"Article 111146"},"PeriodicalIF":6.3000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"UNSX-HRNet: Modeling anatomical uncertainty for landmark detection in total hip arthroplasty\",\"authors\":\"Jiaxin Wan , Lin Liu , Haoran Wang , Liangwei Li , Wei Li , Shuheng Kou , Runtian Li , Jiayi Tang , Juanxiu Liu , Jing Zhang , Xiaohui Du , Ruqian Hao\",\"doi\":\"10.1016/j.compbiomed.2025.111146\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Accurate detection of anatomical landmarks from radiographic images is critical for total hip arthroplasty (THA) surgical planning and postoperative evaluation. However, existing methods face significant challenges in unstructured data, such as irregular patient postures or occluded landmarks, which hinder their robustness and reliability. This study aims to develop an advanced deep learning framework to address these challenges, by leveraging uncertainty estimation to handle unstructured data and assigning uncertainty scores to predicted landmarks, thereby alerting clinicians to focus on these results.</div></div><div><h3>Methods</h3><div>We propose Unstructured X-ray - High-Resolution Net (UNSX-HRNet), a framework that integrates high-resolution networks with uncertainty estimation based on anatomical relationships to predict landmarks without relying on a fixed number of points. The method suppresses low-certainty landmarks to accurately handle unstructured data while highlighting the certainty level of each landmark to provide correction guidance. The model was trained and tested on both structured and unstructured datasets, with performance evaluated using multiple precision metrics.</div></div><div><h3>Results</h3><div>Experimental results demonstrate that UNSX-HRNet achieves improvement, exceeding 60 % across multiple evaluation metrics when applied to unstructured datasets. On structured datasets, the framework maintains high performance, showcasing its robustness and adaptability across varying data conditions.</div></div><div><h3>Conclusions</h3><div>UNSX-HRNet offers a reliable and automated solution for THA landmark detection, addressing the challenges of unstructured data through uncertainty-aware predictions. This approach not only improves accuracy but also provides actionable insights for clinicians, contributing to the development of AI-driven expert systems for surgical planning and monitoring.</div></div>\",\"PeriodicalId\":10578,\"journal\":{\"name\":\"Computers in biology and medicine\",\"volume\":\"198 \",\"pages\":\"Article 111146\"},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computers in biology and medicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0010482525014994\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computers in biology and medicine","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010482525014994","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
UNSX-HRNet: Modeling anatomical uncertainty for landmark detection in total hip arthroplasty
Background
Accurate detection of anatomical landmarks from radiographic images is critical for total hip arthroplasty (THA) surgical planning and postoperative evaluation. However, existing methods face significant challenges in unstructured data, such as irregular patient postures or occluded landmarks, which hinder their robustness and reliability. This study aims to develop an advanced deep learning framework to address these challenges, by leveraging uncertainty estimation to handle unstructured data and assigning uncertainty scores to predicted landmarks, thereby alerting clinicians to focus on these results.
Methods
We propose Unstructured X-ray - High-Resolution Net (UNSX-HRNet), a framework that integrates high-resolution networks with uncertainty estimation based on anatomical relationships to predict landmarks without relying on a fixed number of points. The method suppresses low-certainty landmarks to accurately handle unstructured data while highlighting the certainty level of each landmark to provide correction guidance. The model was trained and tested on both structured and unstructured datasets, with performance evaluated using multiple precision metrics.
Results
Experimental results demonstrate that UNSX-HRNet achieves improvement, exceeding 60 % across multiple evaluation metrics when applied to unstructured datasets. On structured datasets, the framework maintains high performance, showcasing its robustness and adaptability across varying data conditions.
Conclusions
UNSX-HRNet offers a reliable and automated solution for THA landmark detection, addressing the challenges of unstructured data through uncertainty-aware predictions. This approach not only improves accuracy but also provides actionable insights for clinicians, contributing to the development of AI-driven expert systems for surgical planning and monitoring.
期刊介绍:
Computers in Biology and Medicine is an international forum for sharing groundbreaking advancements in the use of computers in bioscience and medicine. This journal serves as a medium for communicating essential research, instruction, ideas, and information regarding the rapidly evolving field of computer applications in these domains. By encouraging the exchange of knowledge, we aim to facilitate progress and innovation in the utilization of computers in biology and medicine.