Courtney M. Collins, Anahita Jalilvand, Whitney Kellett, Holly Baselice, Jon Wisler
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Antecedent traumatic injuries independently predict higher 90-day mortality for patients admitted to the ICU with surgical sepsis
Introduction
Sepsis and trauma are leading causes of mortality. We hypothesize that antecedent trauma contributes to worse outcomes.
Methods
A single-institution retrospective study of patients admitted to the SICU between September 2013–January 2019 who met Sepsis III criteria. 1401 patients were included, 7.8 % (n = 106) had preceding trauma. Cox regression was used to model in-hospital death and 90-day mortality. Kaplan-Meier 90- Day Survival Curve was calculated based on trauma status.
Results
Antecedent trauma was associated with in-hospital mortality (p = 0.03). Trauma, transfer status, age, Charlson comorbidity index, admission lactate and SOFA score were all independent predictors of in-hospital and 90-day mortality (p < 0.005). 90-day survival curve showed a trend towards decreasing survival for the trauma cohort (p = 0.02).
Conclusion
Our findings indicate antecedent trauma may have significant impact on patient outcomes. Further investigation is necessary to explore the underlying mechanisms linking trauma and sepsis.
期刊介绍:
The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.