{"title":"吲达帕胺干扰液相色谱串联质谱法测定醛固酮。","authors":"Amy R Frank, Susan Johnston","doi":"10.1177/00045632251388531","DOIUrl":null,"url":null,"abstract":"<p><p>The aldosterone renin ratio (ARR) is used as a screening test for primary aldosteronism (PA), this requires measurement of both aldosterone and renin. Aldosterone is usually measured using immunoassay or liquid chromatography mass spectrometry techniques. Anti-hypertensive medications should be discontinued prior to screening as they can interfere with interpretation of results. Indapamide is a thiazide like diuretic commonly used in the treatment of hypertension. NICE guidance, NG136 (2019) recommends the use of indapamide over more conventional thiazide diuretics. Indapamide has been noted to cause interference in a liquid chromatography mass spectrometry method by interfering in the measurement of aldosterone-d4 internal standard. This leads to falsely increased concentrations of aldosterone which can lead to unnecessary further investigations.</p>","PeriodicalId":8005,"journal":{"name":"Annals of Clinical Biochemistry","volume":" ","pages":"45632251388531"},"PeriodicalIF":1.0000,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Indapamide interference in liquid chromatography tandem mass spectrometry aldosterone assay.\",\"authors\":\"Amy R Frank, Susan Johnston\",\"doi\":\"10.1177/00045632251388531\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The aldosterone renin ratio (ARR) is used as a screening test for primary aldosteronism (PA), this requires measurement of both aldosterone and renin. Aldosterone is usually measured using immunoassay or liquid chromatography mass spectrometry techniques. Anti-hypertensive medications should be discontinued prior to screening as they can interfere with interpretation of results. Indapamide is a thiazide like diuretic commonly used in the treatment of hypertension. NICE guidance, NG136 (2019) recommends the use of indapamide over more conventional thiazide diuretics. Indapamide has been noted to cause interference in a liquid chromatography mass spectrometry method by interfering in the measurement of aldosterone-d4 internal standard. This leads to falsely increased concentrations of aldosterone which can lead to unnecessary further investigations.</p>\",\"PeriodicalId\":8005,\"journal\":{\"name\":\"Annals of Clinical Biochemistry\",\"volume\":\" \",\"pages\":\"45632251388531\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Clinical Biochemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/00045632251388531\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Clinical Biochemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00045632251388531","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Indapamide interference in liquid chromatography tandem mass spectrometry aldosterone assay.
The aldosterone renin ratio (ARR) is used as a screening test for primary aldosteronism (PA), this requires measurement of both aldosterone and renin. Aldosterone is usually measured using immunoassay or liquid chromatography mass spectrometry techniques. Anti-hypertensive medications should be discontinued prior to screening as they can interfere with interpretation of results. Indapamide is a thiazide like diuretic commonly used in the treatment of hypertension. NICE guidance, NG136 (2019) recommends the use of indapamide over more conventional thiazide diuretics. Indapamide has been noted to cause interference in a liquid chromatography mass spectrometry method by interfering in the measurement of aldosterone-d4 internal standard. This leads to falsely increased concentrations of aldosterone which can lead to unnecessary further investigations.
期刊介绍：
Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine.
Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal''s scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals.
Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).
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