Xiang Ma, Weisong Xue, Zuolin Zhou, Qiong He, Feng Yang, Ningchao Du, Jun Sun, Huiwen Ning, NiNi Liu, Ying Luo, Jian Cai
{"title":"猪脱细胞膀胱基质填充治疗肛瘘的初步研究：一项单中心队列研究。","authors":"Xiang Ma, Weisong Xue, Zuolin Zhou, Qiong He, Feng Yang, Ningchao Du, Jun Sun, Huiwen Ning, NiNi Liu, Ying Luo, Jian Cai","doi":"10.1111/ans.70342","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to preliminarily assess the effectiveness of a novel biomaterial, porcine acellular bladder matrix (PABM), in filling fistula tracts.</p><p><strong>Summary of background data: </strong>Anal fistula plugs (AFPs) made from biomaterials are designed to fill fistulas, promote tissue healing, and prevent anal sphincter damage caused by conventional surgeries.</p><p><strong>Methods: </strong>This single-center cross-sectional study evaluated PABM-AFP treatment for anal fistulas between May 2023 and May 2024. Twenty-eight patients diagnosed with anal fistulas underwent PABM-AFP filling, with follow-up conducted for 6-12 months postoperatively.</p><p><strong>Results: </strong>The overall success rate was 89.3%, with an efficacy rate of 90.6% for all treated fistulas. Of the three patients who experienced treatment failure, two recovered after receiving thread-ligating treatment, and the remaining patient who had Crohn's disease experienced partial healing. The mean healing time was 5 weeks, and the average follow-up duration was 7 months. No adverse complications were reported.</p><p><strong>Conclusions: </strong>PABM-AFP is a promising, safe, and effective treatment option for anal fistulas. This study provides valuable preliminary data to support the clinical use of PABM-AFP.</p>","PeriodicalId":8158,"journal":{"name":"ANZ Journal of Surgery","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Pilot Study of Porcine Acellular Bladder Matrix Filling in the Treatment of Anal Fistulas: A Single-Center Cohort Study.\",\"authors\":\"Xiang Ma, Weisong Xue, Zuolin Zhou, Qiong He, Feng Yang, Ningchao Du, Jun Sun, Huiwen Ning, NiNi Liu, Ying Luo, Jian Cai\",\"doi\":\"10.1111/ans.70342\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to preliminarily assess the effectiveness of a novel biomaterial, porcine acellular bladder matrix (PABM), in filling fistula tracts.</p><p><strong>Summary of background data: </strong>Anal fistula plugs (AFPs) made from biomaterials are designed to fill fistulas, promote tissue healing, and prevent anal sphincter damage caused by conventional surgeries.</p><p><strong>Methods: </strong>This single-center cross-sectional study evaluated PABM-AFP treatment for anal fistulas between May 2023 and May 2024. Twenty-eight patients diagnosed with anal fistulas underwent PABM-AFP filling, with follow-up conducted for 6-12 months postoperatively.</p><p><strong>Results: </strong>The overall success rate was 89.3%, with an efficacy rate of 90.6% for all treated fistulas. Of the three patients who experienced treatment failure, two recovered after receiving thread-ligating treatment, and the remaining patient who had Crohn's disease experienced partial healing. The mean healing time was 5 weeks, and the average follow-up duration was 7 months. No adverse complications were reported.</p><p><strong>Conclusions: </strong>PABM-AFP is a promising, safe, and effective treatment option for anal fistulas. This study provides valuable preliminary data to support the clinical use of PABM-AFP.</p>\",\"PeriodicalId\":8158,\"journal\":{\"name\":\"ANZ Journal of Surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-10-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ANZ Journal of Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/ans.70342\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ANZ Journal of Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ans.70342","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"SURGERY","Score":null,"Total":0}
A Pilot Study of Porcine Acellular Bladder Matrix Filling in the Treatment of Anal Fistulas: A Single-Center Cohort Study.
Objective: This study aimed to preliminarily assess the effectiveness of a novel biomaterial, porcine acellular bladder matrix (PABM), in filling fistula tracts.
Summary of background data: Anal fistula plugs (AFPs) made from biomaterials are designed to fill fistulas, promote tissue healing, and prevent anal sphincter damage caused by conventional surgeries.
Methods: This single-center cross-sectional study evaluated PABM-AFP treatment for anal fistulas between May 2023 and May 2024. Twenty-eight patients diagnosed with anal fistulas underwent PABM-AFP filling, with follow-up conducted for 6-12 months postoperatively.
Results: The overall success rate was 89.3%, with an efficacy rate of 90.6% for all treated fistulas. Of the three patients who experienced treatment failure, two recovered after receiving thread-ligating treatment, and the remaining patient who had Crohn's disease experienced partial healing. The mean healing time was 5 weeks, and the average follow-up duration was 7 months. No adverse complications were reported.
Conclusions: PABM-AFP is a promising, safe, and effective treatment option for anal fistulas. This study provides valuable preliminary data to support the clinical use of PABM-AFP.
期刊介绍：
ANZ Journal of Surgery is published by Wiley on behalf of the Royal Australasian College of Surgeons to provide a medium for the publication of peer-reviewed original contributions related to clinical practice and/or research in all fields of surgery and related disciplines. It also provides a programme of continuing education for surgeons. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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