血液病恶性肿瘤的肿瘤学-心脏病学:从心脏病学的角度看。

Hiroshi Akazawa
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引用次数: 0

摘要

癌症治疗的最新进展改善了癌症患者的长期预后,增加了管理心血管并发症的重要性,这些并发症不仅来自癌症本身,也来自化疗、放射治疗和免疫治疗。在血液学领域,各种化疗药物如蒽环类药物、免疫调节药物、BCR-ABL酪氨酸激酶抑制剂、蛋白酶体抑制剂和免疫检查点抑制剂引起的心血管并发症受到严重关注。化疗对心血管系统有各种各样的影响,单个分子靶向药物心血管毒性的分子机制仍有待精确定义。这种“肿瘤-心脏病学”方法有望加强肿瘤学/血液学和心脏病学专家在临床实践、研究和教育方面的跨学科合作,以保护癌症患者和幸存者免受心血管并发症的侵害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Onco-cardiology in hematological malignancy: from the perspective of cardiology].

Recent advances in cancer therapy have improved the long-term outcomes of cancer patients, increasing the importance of managing cardiovascular complications arising not only from cancer itself but also from chemotherapy, radiation therapy, and immunotherapy. In the field of hematology, there are serious concerns about cardiovascular complications of various chemotherapeutic agents such as anthracyclines, immunomodulatory drugs, BCR-ABL tyrosine kinase inhibitors, proteasome inhibitors, and immune checkpoint inhibitors. Chemotherapy has a wide variety of effects on the cardiovascular system, and the molecular mechanisms underlying the cardiovascular toxicities of individual molecularly targeted agents remain to be precisely defined. This "Onco-Cardiology" approach is expected to enhance interdisciplinary collaboration between oncology/hematology and cardiology specialists across clinical practice, research, and education to protect cancer patients and survivors from cardiovascular complications.

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