了解肌肉活检疼痛:期间和之后会发生什么

IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY
B. Labella , G. Brochier , M. Beuvin , A. Chanut , E. Lacene , C. Labasse , A. Madelaine , F. Levy-Borsato , S. Leonard-Louis , G. Bassez , D. Seilhean , T. Evangelista
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引用次数: 0

摘要

开放式肌肉活检(OBM)是一种有价值的诊断工具,但患者经常表达对手术风险和潜在不适的担忧。本观察性研究的目的是描述手术期间和手术后疼痛的特征,并评估可能影响患者疼痛感知的预后因素。在巴黎Pitié-Salpêtrière医院接受手术并提供知情同意书的18岁患者被纳入研究。在干预前收集临床资料和虚弱评估。手术后,患者完成详细的问卷调查,包括用于疼痛评估的数值评定量表(NRS)和PHQ-9问卷。随访时间分别为15天和30天。84例患者(男性25例)入选,NRS的平均疼痛评分为2.5分。OBM最痛苦的阶段是采血阶段(52/84,61.9%),其次是局麻阶段(17/84,20.2%)。包括医疗沟通、服务舒适度和活检程序在内的总体全球满意度为9/10。63例患者随访期间未见重大并发症。21名患者(38.8%)报告轻度疼痛(NRS 1-3),通常持续48小时,而8名患者(12.7%)经历中度疼痛(NRS 4-6)。总体而言,只有24例患者(38.1%)在手术后接受了镇痛治疗,其中扑热息痛是一线镇痛药(22/24,91.4%),治疗效果良好。介入前焦虑与OBM期间更高的疼痛感无关。OBM期间的疼痛通常是轻微的。手术后,患者通常报告很少或没有不适。因此,手术是一种安全且耐受性良好的手术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
36PUnderstanding muscle biopsy pain: what to expect during and after
Open muscle biopsy (OBM) is a valuable diagnostic tool, but patients frequently express concerns about the surgical risks and potential discomfort. The aim of this observational study is to describe the characteristics of pain encountered during and after OBM and to assess the prognostic factors that may influence patient’s pain perception. Patients aged > 18 years who underwent OBM at the Pitié-Salpêtrière Hospital in Paris and provided informed consent were enrolled in the study. Clinical data and frailty assessment were collected prior to the intervention. Following OBM, patients completed a detailed questionnaire, including the numerical rating scale (NRS) for pain assessment, and the PHQ-9 questionnaire. Follow-up phone calls were performed at 15 and 30 days. Eighty-four patients (25 males) were enrolled, with a mean pain score of 2.5 on the NRS. The most painful phase of the OBM was the sampling collection phase (52/84, 61.9%), followed by the local anesthesia phase (17/84, 20.2%). Overall global satisfaction, including medical communication, service comfort and biopsy procedure, was rated as 9/10. No major complications were observed in the follow-up period, available for 63 patients. Twenty-one patients (38.8%) reported mild pain (NRS 1-3), usually lasting up to 48 hours, while eight patients (12.7%) experienced moderate pain (NRS 4-6). Overall, only twenty-four patients (38.1%) took an antalgic treatment after OBM, with paracetamol being the first line analgesic (22/24, 91.4%), yielding a good therapeutic response. Pre-interventional anxiety wasn’t associated with higher pain perception during OBM. Pain experienced during OBM is usually mild. After OBM, patients generally report little to no discomfort. Therefore, OBM is a safe and well-tolerated procedure.
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来源期刊
Neuromuscular Disorders
Neuromuscular Disorders 医学-临床神经学
CiteScore
4.60
自引率
3.60%
发文量
543
审稿时长
53 days
期刊介绍: This international, multidisciplinary journal covers all aspects of neuromuscular disorders in childhood and adult life (including the muscular dystrophies, spinal muscular atrophies, hereditary neuropathies, congenital myopathies, myasthenias, myotonic syndromes, metabolic myopathies and inflammatory myopathies). The Editors welcome original articles from all areas of the field: • Clinical aspects, such as new clinical entities, case studies of interest, treatment, management and rehabilitation (including biomechanics, orthotic design and surgery). • Basic scientific studies of relevance to the clinical syndromes, including advances in the fields of molecular biology and genetics. • Studies of animal models relevant to the human diseases. The journal is aimed at a wide range of clinicians, pathologists, associated paramedical professionals and clinical and basic scientists with an interest in the study of neuromuscular disorders.
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