钴催化电还原交叉偶联对映选择性合成atropisomer 3- arlindoles。

IF 15.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of the American Chemical Society Pub Date : 2025-10-02 DOI:10.1021/jacs.5c11094

Shi-Shuo Xu,Jian-Feng Guo,Cong Ma,Ping Fang,Tian-Sheng Mei

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引用次数: 0

摘要

研究了钴催化芳基碘化物和吲哚溴化物的对映选择性电还原交叉偶联反应。该策略的特点是反应条件温和，对映体选择性高，底物范围广。值得注意的是，这种方法有效地解决了吲哚底物在2位不具有吸电子取代基的挑战，这是其他策略中尚未解决的限制。

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Enantioselective Synthesis of Atropisomeric 3-Arylindoles via Cobalt-Catalyzed Electroreductive Cross-Coupling.

Cobalt-catalyzed enantioselective electroreductive cross-coupling of aryl iodides and indole bromides has been developed. This strategy is characterized by mild reaction conditions, high enantioselectivities, and a broad substrate scope. Notably, this approach effectively addresses the challenges associated with indole substrates that do not possess electron-withdrawing substituents at the 2-position, a limitation that remains unresolved in other strategies.

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来源期刊

Journal of the American Chemical Society 化学-化学综合

CiteScore

24.40

自引率

6.00%

发文量

2398

审稿时长

1.6 months

期刊介绍： The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.