妇科癌症的表观遗传调控:免疫治疗策略的范式转变。

IF 12.8 1区 医学 Q1 ONCOLOGY
Chenyuan Zhao, Yang Liu, Zhuo Cui
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引用次数: 0

摘要

免疫疗法的最新进展已经改变了妇科癌症的治疗前景;然而,持久的反应仍然受到肿瘤异质性和免疫逃避机制的限制。新出现的证据强调表观遗传修饰包括DNA甲基化、组蛋白修饰和RNA甲基化是肿瘤免疫微环境和免疫治疗效果的关键调节因子。这篇综述全面探讨了这些表观遗传改变如何调节免疫细胞浸润、抗原呈递、免疫检查点表达和宫颈癌、卵巢癌和子宫内膜癌的肿瘤免疫原性。我们还描述了特异性表观遗传酶(如dnmt、hdac、BET和RNA甲基转移酶)在形成免疫反应中的影响,并讨论了靶向这些调节因子使肿瘤对免疫检查点抑制剂、癌症疫苗、基于细胞因子的治疗和过继t细胞治疗敏感的治疗潜力。此外,我们在临床前和临床环境中研究了表观遗传药物如DNMT和HDAC抑制剂与免疫疗法的整合,强调它们克服免疫抵抗的协同能力。通过阐明表观遗传调控和免疫动力学之间的相互作用,本综述强调了向精确免疫表观遗传策略的范式转变,为提高妇科恶性肿瘤的治疗效果提供了一个有希望的框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenetic regulation in gynecological cancers: a paradigm shift in immunotherapy strategies.

Recent advances in immunotherapy have transformed the therapeutic landscape of gynecological cancers; however, durable responses remain limited by tumor heterogeneity and immune evasion mechanisms. Emerging evidence highlights epigenetic modifications comprising of DNA methylation, histone modifications, and RNA methylation as pivotal regulators of the tumor immune microenvironment and immunotherapy efficacy. This review comprehensively explores how these epigenetic alterations modulate immune cell infiltration, antigen presentation, immune checkpoint expression, and tumor immunogenicity across cervical, ovarian, and endometrial cancers. We also delineate the impact of specific epigenetic enzymes, such as DNMTs, HDACs, BET and RNA methyltransferases, in shaping immune responses and discuss the therapeutic potential of targeting these regulators to sensitize tumors to immune checkpoint inhibitors, cancer vaccines, cytokine based treatments and adoptive T-cell therapies. Furthermore, we examine the integration of epigenetic agents such as DNMT and HDAC inhibitors with immunotherapies in preclinical and clinical settings, emphasizing their synergistic capacity to overcome immunoresistance. By illuminating the interplay between epigenetic regulation and immune dynamics, this review underscores a paradigm shift toward precision immunoepigenetic strategies, offering a promising framework for enhancing therapeutic outcomes in gynecological malignancies.

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来源期刊
CiteScore
18.20
自引率
1.80%
发文量
333
审稿时长
1 months
期刊介绍: The Journal of Experimental & Clinical Cancer Research is an esteemed peer-reviewed publication that focuses on cancer research, encompassing everything from fundamental discoveries to practical applications. We welcome submissions that showcase groundbreaking advancements in the field of cancer research, especially those that bridge the gap between laboratory findings and clinical implementation. Our goal is to foster a deeper understanding of cancer, improve prevention and detection strategies, facilitate accurate diagnosis, and enhance treatment options. We are particularly interested in manuscripts that shed light on the mechanisms behind the development and progression of cancer, including metastasis. Additionally, we encourage submissions that explore molecular alterations or biomarkers that can help predict the efficacy of different treatments or identify drug resistance. Translational research related to targeted therapies, personalized medicine, tumor immunotherapy, and innovative approaches applicable to clinical investigations are also of great interest to us. We provide a platform for the dissemination of large-scale molecular characterizations of human tumors and encourage researchers to share their insights, discoveries, and methodologies with the wider scientific community. By publishing high-quality research articles, reviews, and commentaries, the Journal of Experimental & Clinical Cancer Research strives to contribute to the continuous improvement of cancer care and make a meaningful impact on patients' lives.
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