Tea Soini, Frida Andersson, Maria Lalouni, Marianne Bonnert, Siri Voghera, Brjánn Ljótsson, Marc A Benninga, Arine M Vlieger, Helena J Rolandsdotter, Agneta Uusijärvi, Ola Olén
{"title":"用音频文件对患有肠-脑相互作用障碍的儿童和青少年进行催眠疗法自我练习-瑞典的可行性和初步效果研究。","authors":"Tea Soini, Frida Andersson, Maria Lalouni, Marianne Bonnert, Siri Voghera, Brjánn Ljótsson, Marc A Benninga, Arine M Vlieger, Helena J Rolandsdotter, Agneta Uusijärvi, Ola Olén","doi":"10.1177/17562848251381141","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gut-directed hypnotherapy is effective for treating children with disorders of gut-brain interaction, but is currently unavailable in Sweden.</p><p><strong>Objectives: </strong>To evaluate the within-group effect and feasibility of a Swedish adaptation of an audio-based gut-directed hypnotherapy program.</p><p><strong>Design: </strong>Uncontrolled within-group feasibility study.</p><p><strong>Methods: </strong>Children and adolescents (aged 8-17) diagnosed with irritable bowel syndrome, functional abdominal pain, or functional dyspepsia (per Rome IV criteria) participated in a 12-week online hypnotherapy program. The program used audio files that were translated and adapted from a validated Dutch protocol. Data were collected at baseline, during treatment, and post-treatment. The primary outcome was gastrointestinal symptoms, measured by the PedsQL Gastrointestinal Symptoms Short Scale. Secondary outcomes included pain intensity and frequency, quality of life, stress, depression, anxiety, school absenteeism, and treatment credibility and satisfaction. Analyses with linear mixed models were used to estimate means, standard deviations, and effect sizes (Cohen's <i>d</i>).</p><p><strong>Results: </strong>Of the 32 patients included in the study, 25 (78%) completed the program and provided post-treatment data. Significant improvements in PedsQL gastro score were observed, with moderate effect size in child reports (<i>d</i> = 0.63, <i>p</i> < .001) and large effect size in parent reports (<i>d</i> = 0.81, <i>p</i> < .001). Clinically significant improvement (>30%) in gastrointestinal symptoms was achieved by 40% of completers. Pain intensity showed a modest decrease, with small effect sizes in both child (<i>d</i> = 0.24, <i>p</i> < .005) and parent reports (<i>d</i> = 0.28, <i>p</i> < .005).</p><p><strong>Conclusion: </strong>The Swedish version of audio-based gut-directed hypnotherapy appears feasible and acceptable, with promising symptom improvements in children with functional gastrointestinal disorders. A randomized controlled trial should be conducted to confirm efficacy and identify predictors of treatment response.</p>","PeriodicalId":48770,"journal":{"name":"Therapeutic Advances in Gastroenterology","volume":"18 ","pages":"17562848251381141"},"PeriodicalIF":3.4000,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477360/pdf/","citationCount":"0","resultStr":"{\"title\":\"Hypnotherapy self-exercises with audio files for children and adolescents with disorders of gut-brain interaction-a study of feasibility and preliminary effects in Sweden.\",\"authors\":\"Tea Soini, Frida Andersson, Maria Lalouni, Marianne Bonnert, Siri Voghera, Brjánn Ljótsson, Marc A Benninga, Arine M Vlieger, Helena J Rolandsdotter, Agneta Uusijärvi, Ola Olén\",\"doi\":\"10.1177/17562848251381141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Gut-directed hypnotherapy is effective for treating children with disorders of gut-brain interaction, but is currently unavailable in Sweden.</p><p><strong>Objectives: </strong>To evaluate the within-group effect and feasibility of a Swedish adaptation of an audio-based gut-directed hypnotherapy program.</p><p><strong>Design: </strong>Uncontrolled within-group feasibility study.</p><p><strong>Methods: </strong>Children and adolescents (aged 8-17) diagnosed with irritable bowel syndrome, functional abdominal pain, or functional dyspepsia (per Rome IV criteria) participated in a 12-week online hypnotherapy program. The program used audio files that were translated and adapted from a validated Dutch protocol. Data were collected at baseline, during treatment, and post-treatment. The primary outcome was gastrointestinal symptoms, measured by the PedsQL Gastrointestinal Symptoms Short Scale. Secondary outcomes included pain intensity and frequency, quality of life, stress, depression, anxiety, school absenteeism, and treatment credibility and satisfaction. Analyses with linear mixed models were used to estimate means, standard deviations, and effect sizes (Cohen's <i>d</i>).</p><p><strong>Results: </strong>Of the 32 patients included in the study, 25 (78%) completed the program and provided post-treatment data. Significant improvements in PedsQL gastro score were observed, with moderate effect size in child reports (<i>d</i> = 0.63, <i>p</i> < .001) and large effect size in parent reports (<i>d</i> = 0.81, <i>p</i> < .001). Clinically significant improvement (>30%) in gastrointestinal symptoms was achieved by 40% of completers. Pain intensity showed a modest decrease, with small effect sizes in both child (<i>d</i> = 0.24, <i>p</i> < .005) and parent reports (<i>d</i> = 0.28, <i>p</i> < .005).</p><p><strong>Conclusion: </strong>The Swedish version of audio-based gut-directed hypnotherapy appears feasible and acceptable, with promising symptom improvements in children with functional gastrointestinal disorders. A randomized controlled trial should be conducted to confirm efficacy and identify predictors of treatment response.</p>\",\"PeriodicalId\":48770,\"journal\":{\"name\":\"Therapeutic Advances in Gastroenterology\",\"volume\":\"18 \",\"pages\":\"17562848251381141\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477360/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic Advances in Gastroenterology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/17562848251381141\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/17562848251381141","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：肠道导向催眠疗法对治疗儿童肠脑相互作用障碍是有效的，但目前在瑞典尚不可用。目的：评估瑞典一种基于音频的肠道导向催眠治疗方案的组内效果和可行性。设计：组内非受控可行性研究。方法：诊断为肠易激综合征、功能性腹痛或功能性消化不良（根据Rome IV标准）的儿童和青少年（8-17岁）参加了为期12周的在线催眠治疗项目。该程序使用的音频文件是从经过验证的荷兰协议翻译和改编的。在基线、治疗期间和治疗后收集数据。主要终点是胃肠道症状，由PedsQL胃肠道症状短量表测量。次要结局包括疼痛强度和频率、生活质量、压力、抑郁、焦虑、旷课、治疗可信度和满意度。采用线性混合模型进行分析，估计均值、标准差和效应大小（Cohen’s d）。结果：在纳入研究的32例患者中，25例（78%）完成了治疗方案并提供了治疗后数据。在PedsQL胃肠评分方面观察到显著改善，在儿童报告中有中等效应大小（d = 0.63, p d = 0.81, p 30%）， 40%的完成者实现了胃肠症状的改善。结论：瑞典版本的基于音频的肠道定向催眠疗法似乎是可行和可接受的，对功能性胃肠疾病儿童的症状改善有希望。应进行随机对照试验以确认疗效并确定治疗反应的预测因素。
Hypnotherapy self-exercises with audio files for children and adolescents with disorders of gut-brain interaction-a study of feasibility and preliminary effects in Sweden.
Background: Gut-directed hypnotherapy is effective for treating children with disorders of gut-brain interaction, but is currently unavailable in Sweden.
Objectives: To evaluate the within-group effect and feasibility of a Swedish adaptation of an audio-based gut-directed hypnotherapy program.
Methods: Children and adolescents (aged 8-17) diagnosed with irritable bowel syndrome, functional abdominal pain, or functional dyspepsia (per Rome IV criteria) participated in a 12-week online hypnotherapy program. The program used audio files that were translated and adapted from a validated Dutch protocol. Data were collected at baseline, during treatment, and post-treatment. The primary outcome was gastrointestinal symptoms, measured by the PedsQL Gastrointestinal Symptoms Short Scale. Secondary outcomes included pain intensity and frequency, quality of life, stress, depression, anxiety, school absenteeism, and treatment credibility and satisfaction. Analyses with linear mixed models were used to estimate means, standard deviations, and effect sizes (Cohen's d).
Results: Of the 32 patients included in the study, 25 (78%) completed the program and provided post-treatment data. Significant improvements in PedsQL gastro score were observed, with moderate effect size in child reports (d = 0.63, p < .001) and large effect size in parent reports (d = 0.81, p < .001). Clinically significant improvement (>30%) in gastrointestinal symptoms was achieved by 40% of completers. Pain intensity showed a modest decrease, with small effect sizes in both child (d = 0.24, p < .005) and parent reports (d = 0.28, p < .005).
Conclusion: The Swedish version of audio-based gut-directed hypnotherapy appears feasible and acceptable, with promising symptom improvements in children with functional gastrointestinal disorders. A randomized controlled trial should be conducted to confirm efficacy and identify predictors of treatment response.
期刊介绍：
Therapeutic Advances in Gastroenterology is an open access journal which delivers the highest quality peer-reviewed original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of gastrointestinal and hepatic disorders. The journal has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in gastroenterology and related disciplines, providing an online forum for rapid dissemination of recent research and perspectives in this area.
The editors welcome original research articles across all areas of gastroenterology and hepatology.
The journal publishes original research articles and review articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports will also be considered.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
