一项前瞻性队列研究:潮气量挑战期间颈内静脉呼吸变化预测保护性通气下腰椎手术的容量反应性。

IF 4.7 2区 医学 Q1 CRITICAL CARE MEDICINE
Mimi Wu, Jie Xu, Xiaojie Liu, Yuanyuan Dong, Yu'e Sun, Xiaoping Gu, Jinhua Bo
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引用次数: 0

摘要

背景:颈内静脉呼吸变异(IJVV)被认为是液体反应性的动态预测指标。然而,在俯卧位低潮气量(Vt)通气的患者中,其效用有限。我们进行了这项研究,以确定Vt从预测体重(PBW)的6到8 ml kg-1的短暂增加,即“潮气量挑战(TVC)”,是否提高了低Vt通气后路腰椎手术患者IJVV的可行性。方法:这是一项在手术室进行的前瞻性研究。研究患者在基线时(Vt为6 ml kg-1 PBW),在Vt增加至8 ml kg-1 PBW 1分钟期间,在转向Trendelenburg操作1分钟期间,以及在液体给药后。测量IJVV的基线值、脉压变化(PPV)和行程体积变化(SVV)[分别为IJVV6、PPV6和SVV6],以及TVC期间IJVV的变化(ΔIJVV6-8)。同时记录Trendelenburg操作时心脏指数的变化(ΔCItrend)。容量反应性以ΔCItrend≥8%来定义。主要结果是确定ΔIJVV6-8在预测俯卧位低Vt通气时的容量反应性。次要结果包括IJVV6、PPV6和SVV6诊断性能在预测该手术环境中容量反应性的估计。结果:61例患者纳入研究,其中31例(50.82%)被认为是容量反应。ΔIJVV6-8预测容量反应性的受者工作特征曲线下面积(AUC)为0.96 (95% CI 0.88-0.99), P 6-8显著高于IJVV6、PPV6和SVV6, DeLong检验证实了这一点(P = 0.04, P)。结论:在低Vt通气的后路腰椎手术患者中,TVC期间IJVV的变化能有效预测容量反应性,在该手术背景下,IJVV的变化比IJVV、PPV和SVV更可靠。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in internal jugular vein respiratory variation during tidal volume challenge predict volume responsiveness in lumbar surgery under protective ventilation: a prospective cohort study.

Background: Internal jugular vein respiratory variation (IJVV) has been proposed as a dynamic predictor of fluid responsiveness. However, its utility is limited in patients with low tidal volume (Vt) ventilation in the prone position. We conducted this study to determine whether a transient increase in Vt from 6 to 8 ml kg-1 of the predicted body weight (PBW), which is the "tidal volume challenge (TVC)", improves the feasibility of the IJVV in patients undergoing posterior lumbar surgery ventilated with a low Vt.

Methods: This was a prospective study conducted in the operating room. Patients were studied at baseline (a Vt of 6 ml kg-1 PBW), during a 1 min increase in the Vt to 8 ml kg-1 of the PBW, during a 1 min shift to the Trendelenburg maneuver, and after fluid administration. Baseline values of the IJVV, pulse pressure variation (PPV), and stroke volume variation (SVV) [IJVV6, PPV6, and SVV6, respectively], and the changes in the IJVV during a TVC (ΔIJVV6-8) were measured. The change in cardiac index during a Trendelenburg maneuver (ΔCItrend) was also recorded. Volume responsiveness was defined by a ΔCItrend ≥ 8%. The primary outcome was determination of the ΔIJVV6-8 in predicting volume responsiveness during low Vt ventilation in the prone position. The secondary outcomes included an estimation of the IJVV6, PPV6, and SVV6 diagnostic performances in predicting volume responsiveness in this surgical setting.

Results: Sixty-one patients were included in the study, 31 (50.82%) of whom were deemed volume responsive. The ΔIJVV6-8 predicted volume responsiveness with area under the receiver operating characteristic curve (AUC) of 0.96 (95% CI 0.88-0.99; P < 0.001), with a sensitivity of 96.77% and a specificity of 86.67%. In addition, the AUC for ΔIJVV6-8 was significantly higher than that for IJVV6, PPV6, and SVV6, as confirmed by DeLong's test (P = 0.04, P < 0.001, and P = 0.01, respectively).

Conclusions: In patients undergoing posterior lumbar surgery with low Vt ventilation, changes in IJVV during a TVC effectively predict volume responsiveness and are more reliable than IJVV, PPV, and SVV in this surgical context.

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来源期刊
Journal of Intensive Care
Journal of Intensive Care Medicine-Critical Care and Intensive Care Medicine
CiteScore
11.90
自引率
1.40%
发文量
51
审稿时长
15 weeks
期刊介绍: "Journal of Intensive Care" is an open access journal dedicated to the comprehensive coverage of intensive care medicine, providing a platform for the latest research and clinical insights in this critical field. The journal covers a wide range of topics, including intensive and critical care, trauma and surgical intensive care, pediatric intensive care, acute and emergency medicine, perioperative medicine, resuscitation, infection control, and organ dysfunction. Recognizing the importance of cultural diversity in healthcare practices, "Journal of Intensive Care" also encourages submissions that explore and discuss the cultural aspects of intensive care, aiming to promote a more inclusive and culturally sensitive approach to patient care. By fostering a global exchange of knowledge and expertise, the journal contributes to the continuous improvement of intensive care practices worldwide.
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