干扰素谱和自身抗体对类风湿关节炎的治疗效果分层。

IF 7 1区医学 Q1 IMMUNOLOGY

Journal of autoimmunity Pub Date : 2025-09-30 DOI:10.1016/j.jaut.2025.103490

Shoichi Fukui , Tohru Michitsuji , Yushiro Endo , Ayako Nishino , Kaori Furukawa , Toshimasa Shimizu , Masataka Umeda , Remi Sumiyoshi , Tomohiro Koga , Naoki Iwamoto , Mami Tamai , Tomoki Origuchi , K.A. van Schie , Yukitaka Ueki , Nobutaka Eiraku , Tamami Yoshitama , Naoki Matsuoka , Takahisa Suzuki , Akitomo Okada , Hiroaki Hamada , Shin-ya Kawashiri

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引用次数: 0

摘要

尽管治疗取得了进展，但一些类风湿性关节炎（RA）患者无法通过生物/靶向合成DMARDs获得缓解。我们对200名患者进行了前瞻性评估，以确定干扰素谱和自身抗体是否能预测治疗结果。类风湿因子与IFN-γ水平呈显著正相关。高IFN-γ/低IFN-α2谱的患者获得了更高的缓解率，并表现出B细胞刺激因子升高，具有不同的免疫聚类模式。该组对IL-6抑制剂表现出更好的反应。抗氨甲酰化蛋白IgM抗体组间差异显著。干扰素分析为类风湿关节炎的个性化治疗选择提供了一种实用的筛选方法。

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Treatment outcomes stratified by interferon profile and autoantibodies in rheumatoid arthritis

Despite treatment advances, some rheumatoid arthritis (RA) patients fail to achieve remission with biological/targeted synthetic DMARDs. We prospectively evaluated 200 patients to determine if interferon profiles and autoantibodies predict treatment outcomes. A significant positive correlation between rheumatoid factor and IFN-γ levels was observed. Patients with high IFN-γ/low IFN-α2 profiles achieved significantly higher remission rates and demonstrated elevated B cell-stimulating cytokines with distinct immunological clustering patterns. This group showed superior responses to IL-6 inhibitors. Anti-carbamylated protein IgM antibodies differed significantly between groups. Interferon profiling offers a practical screening approach for personalized therapy selection in RA.

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来源期刊

Journal of autoimmunity 医学-免疫学

CiteScore

27.90

自引率

1.60%

发文量

117

审稿时长

17 days

期刊介绍： The Journal of Autoimmunity serves as the primary publication for research on various facets of autoimmunity. These include topics such as the mechanism of self-recognition, regulation of autoimmune responses, experimental autoimmune diseases, diagnostic tests for autoantibodies, as well as the epidemiology, pathophysiology, and treatment of autoimmune diseases. While the journal covers a wide range of subjects, it emphasizes papers exploring the genetic, molecular biology, and cellular aspects of the field. The Journal of Translational Autoimmunity, on the other hand, is a subsidiary journal of the Journal of Autoimmunity. It focuses specifically on translating scientific discoveries in autoimmunity into clinical applications and practical solutions. By highlighting research that bridges the gap between basic science and clinical practice, the Journal of Translational Autoimmunity aims to advance the understanding and treatment of autoimmune diseases.