抑郁症与代谢功能障碍相关的脂肪变性肝病之间的关系:paracelsus 10,000研究的横断面分析

IF 6.1 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Florian Koutny, Vanessa Frey, Christian Datz, Sophie Gensluckner, Julian Prosenz, Patrick Langthaler, Andreas Maieron, Maria Flamm, Daniel Weghuber, Bernhard Iglseder, Eugen Trinka, Bernhard Paulweber, Elmar Aigner, Bernhard Wernly
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引用次数: 0

摘要

背景和目的:抑郁症与肥胖和代谢综合征有关,但其与代谢功能障碍相关的脂肪变性肝病(MASLD)的独立关联尚不清楚。我们研究了抑郁症状和MASLD之间的关联,独立于其他危险因素。方法:我们分析了Paracelsus 10,000研究中7433名参与者的横断面数据。评估抑郁(BDI-II bbb13)和MASLD (FLI≥60 +≥1个心脏代谢危险因素)。使用泊松和线性回归模型对人口统计学、生活方式因素、代谢综合征和抗抑郁药的使用进行了调整。亚组分析和交互作用分析探讨了效果的改变。结果:MASLD在有抑郁症状的参与者中比无抑郁症状的参与者更普遍(37% vs. 27%)。结论:在这项基于人群的大型横断面研究中,发现抑郁症状与MASLD相关,独立于代谢危险因素和抗抑郁药的使用。然而,考虑到观察设计和抗抑郁药类型、剂量、适应症和依从性的有限细节,研究结果应谨慎解释,不能支持因果结论。然而,研究结果表明,心理健康因素可能与MASLD筛查和预防策略有关。需要进一步的研究来探索抗抑郁治疗是否以及如何与肝脏健康相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between depression and metabolic dysfunction-associated steatotic liver disease: a cross-sectional analysis from the paracelsus 10,000 Study.

Background and aims: Depression is linked to obesity and metabolic syndrome, but its independent association with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. We examined the association between depressive symptoms and MASLD, independent of other risk factors.

Methods: We analyzed cross-sectional data from 7433 participants of the Paracelsus 10,000 study. Depression (BDI-II > 13) and MASLD (FLI ≥ 60 plus ≥ 1 cardiometabolic risk factor) were assessed. Associations were examined using Poisson and linear regression models adjusted for demographics, lifestyle factors, metabolic syndrome, and antidepressant use. Subgroup and interaction analyses explored effect modification.

Results: MASLD was more prevalent in participants with depressive symptoms than those without (37% vs. 27%, p < 0.01). Depressive symptoms were independently associated with MASLD (adjusted incidence rate ratio: 1.25, 95% CI: 1.13-1.39, p < 0.01), with consistent findings using continuous BDI-II scores. The association remained robust across subgroups defined by age, metabolic syndrome, education, smoking status, and antidepressant use. No significant differences were observed in fibrosis markers (APRI and FIB-4).

Conclusion: In this large, population-based cross-sectional study, depressive symptoms were found to be associated with MASLD, independent of metabolic risk factors and antidepressant use. However, given the observational design and limited detail on antidepressant type, dose, indication, and adherence, the findings should be interpreted with caution and do not support causal conclusions. Nevertheless, findings suggest that mental health considerations may be relevant in MASLD screening and prevention strategies. Further research is needed to explore whether and how antidepressant therapy may relate to liver health.

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来源期刊
Hepatology International
Hepatology International 医学-胃肠肝病学
CiteScore
10.90
自引率
3.00%
发文量
167
审稿时长
6-12 weeks
期刊介绍: Hepatology International is the official journal of the Asian Pacific Association for the Study of the Liver (APASL). This is a peer-reviewed journal featuring articles written by clinicians, clinical researchers and basic scientists is dedicated to research and patient care issues in hepatology. This journal will focus mainly on new and emerging technologies, cutting-edge science and advances in liver and biliary disorders. Types of articles published: -Original Research Articles related to clinical care and basic research -Review Articles -Consensus guidelines for diagnosis and treatment -Clinical cases, images -Selected Author Summaries -Video Submissions
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