SZ-HRX和LEHR准直器用于缩短持续时间的123i -碘氟烷脑SPECT/CT的比较:一项幻象研究。

IF 3.2 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Mathieu Pavoine, Kouider-Othmane Kelatma, Clémence Robert, Alexandre Rintaud, Samuel Guigo, Thomas Godefroy, Pierre-Yves Salaün, Solène Querellou, David Bourhis
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引用次数: 0

摘要

背景:123i -碘氟烷单光子发射计算机断层扫描与计算机断层扫描(SPECT-CT)成像被广泛用于评估帕金森综合征(如帕金森病和非典型变体)的多巴胺能失神经。标准成像通常使用低能量高分辨率(LEHR)平行孔准直器,这需要较长的采集时间和最小的源到探测器距离来优化空间分辨率。最近,Smart-Zoom高分辨率和扩展放大体积(SZ-HRX)解决方案专为神经学应用而设计。它结合了多焦点准直器和专用重建算法,有望减少采集时间,并通过允许探测器远离头部来改善患者的舒适度。本研究的目的是比较SZ-HRX系统与LEHR准直器的性能。方法:用不同浓度的碘氟烷填充具有壳核、尾状体和背景5个隔室的纹状体幻体,模拟不同的临床情况。在每个LEHR和SZ-HRX系统上进行层析成像采集。动态获取投影的总和允许用SZ-HRX准直器测试不同的获取持续时间。对灵敏度和空间分辨率进行了评估和比较。根据EANM建议对数据进行重构。计算了两种系统的对比噪声比(CNR)、纹状体背景比(SBR)、变异系数(CV)和归一化不对称指数(NAI),并与LEHR采集进行了比较。为了估计最短的SZ-HRX采集时间,对两个系统之间的所有定量结果进行线性回归计算。结果:SZ-HRX准直具有优于LEHR的性能特征,其CNR、CV和SBR的相对变化分别为+ 99%、-28%和+ 42%,且空间分辨率和不对称指数未发生变化。SZ-HRX系统似乎至少与LEHR系统一样好,最多可减少40%的扫描时间。结论:SZ-HRX准直比LEHR准直在123i -碘氟烷填充纹状体幻体研究中表现出更好的性能特点,可以实现更短的获取时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of SZ-HRX and LEHR collimators for reduced-duration 123I-ioflupane brain SPECT/CT: a phantom study.

Background: 123I-ioflupane Single Photon Emission Computed Tomography with Computed Tomography (SPECT-CT) imaging is widely used to assess dopaminergic denervation in parkinsonian syndromes, such as Parkinson's disease and atypical variants. Standard imaging generally uses low-energy high-resolution (LEHR) parallel-hole collimators, which require long acquisition times and minimal source-to-detector distance to optimize spatial resolution. Recently, the Smart-Zoom High-Resolution and eXtended magnification volume (SZ-HRX) solution was designed specifically for neurological applications. It incorporates multifocal collimators and a dedicated reconstruction algorithm, promising a reduction in acquisition duration, and an improvement in patient comfort by allowing detectors to be positioned further away from the head. The aim of this study is to investigate the performance of SZ-HRX system compared to LEHR collimators.

Methods: A striatal phantom with 5 compartments (putamens, caudates, and background) was filled with different concentrations of 123I-ioflupane to simulate various clinical situations. Tomographic acquisitions were performed on each LEHR and SZ-HRX system. The summation of dynamically acquired projections allowed testing different acquisition durations with the SZ-HRX collimator. Sensitivity and Spatial resolution were assessed and compared. The data were reconstructed according to EANM recommendations. Contrast-to-noise ratio (CNR), striatum-to-background ratio (SBR), coefficient of variation (CV), and normalized asymmetry index (NAI) were calculated for both systems and compared to the LEHR acquisition. To estimate the shortest SZ-HRX acquisition duration, a linear regression of all quantitative results were calculated between the two systems.

Results: SZ-HRX collimation had superior performance characteristics than LEHR, with relative changes in CNR, CV, and SBR of + 99%, -28% and + 42% respectively, without any decrease in spatial resolution or change in asymmetry index. SZ-HRX system seems to be at least as good as LEHR system, up to 40% of scan time reduction.

Conclusion: SZ-HRX collimation showed superior performance characteristics to LEHR collimation in the study of 123I-ioflupane filled striatal phantom, enabling shorter acquisitions.

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来源期刊
EJNMMI Physics
EJNMMI Physics Physics and Astronomy-Radiation
CiteScore
6.70
自引率
10.00%
发文量
78
审稿时长
13 weeks
期刊介绍: EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.
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