介绍e- motion：一种新的术中社会认知映射测试。在规范、精神分裂症和自闭症谱系障碍人群中的三重验证。

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2025-09-30 DOI:10.1007/s00701-025-06661-x

Jesús Martín-Fernández, Nayra Caballero-Estebaranz, Esteban Félez, Pedro Pérez del Rosario, Francisco Rodríguez Pulido, Natalia Navarro-Peris, Fernando Martínez, Andrés Cervio, Isabel Martín-Monzón

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引用次数: 0

摘要

背景：社会认知对日常功能至关重要，因为它影响生活质量、重返工作岗位和人际交往。虽然精神分裂症和自闭症谱系障碍（ASD）一直是社会认知明显受损的典型情况，但新出现的证据表明，高达30%的脑肿瘤患者可能在这一领域存在持续的缺陷。尽管社会认知具有临床意义，但它在神经肿瘤学中的研究仍然不够充分，而且缺乏专门为清醒脑外科手术中使用社会认知而量身定制的术中评估工具。方法：本研究引入了e- motion，一种专门设计的新测试来解决这一空白。电子动作测试包括34个四秒钟的视频刺激，描绘两个超现实的化身（一男一女）表达复杂的情绪。这些虚拟人物是使用一种基于人工智能的面部动作捕捉系统开发的，该系统应用于60名专业演员。在三组中进行验证：(1)健康成年人（n = 226），(2)精神分裂症患者（n = 33）和(3)ASD患者（n = 30）。结果：评估了内部一致性（r -20）、重测信度（ICC）以及与现有社会认知工具（RMET）、Ekman-60人脸测试（Ekman-60F）和社会认知评估电影（MASC）)的相关性。e- motion测试具有较高的整体内部一致性（r -20 = 0.86）和良好的重测信度（ICC 2, 1 = 0.73）。得分与低水平心智化测试（RME: ρ = 0.44; Ekman-60F: ρ = 0.48）和高水平心智化测试（MASC: ρ = 0.57）均呈中等正相关。区分健康参与者与精神分裂症（AUC = 0.89）和ASD （AUC = 0.79）个体的能力很强。结论：电子运动测试是第一个基于人工智能的测试，专门为清醒的大脑绘图而创建。它具有良好的内部一致性和与低水平和高水平心智化测试的显著相关性，使该工具成为一种新的、生态的、有前途的方法，可以在清醒的大脑绘图过程中识别涉及社会认知的关键区域。未来的研究应该进行，以证明其有效性，在脑肿瘤手术期间和之后保留这种复杂的高阶认知结构。

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Introducing e-Motions: a novel intraoperative test for social cognition mapping. Triple validation in normative, schizophrenia, and autism spectrum disorder populations

Background

Social cognition is essential for daily functioning, as it influences quality of life, return to work, and interpersonal communication. While schizophrenia and autism spectrum disorder (ASD) have been the paradigmatic conditions in which social cognition is markedly impaired, emerging evidence suggests that up to 30% patients with brain tumors may experience persistent deficits in this domain. Despite its clinical relevance, social cognition remains insufficiently studied in neuro-oncology and lacks dedicated intraoperative assessment tools specifically tailored for its use during awake brain surgery.

Method

This study introduces e-Motions, a new test designed ad hoc to address this gap. The e-Motions test comprises 34 four-second video stimuli depicting two hyper-realistic avatars (one male, one female) expressing complex emotions. These avatars were developed using an AI-based facial motion capture system applied to 60 professional actors. Validation was performed in three groups: (1) healthy adults (n = 226), (2) individuals with schizophrenia (n = 33), and (3) ASD (n = 30).

Results

Internal consistency (KR-20), test–retest reliability (ICC), and correlations with established social cognition tools (Reading the Mind in the Eyes [RMET], Ekman-60 faces test [Ekman-60F], and the Movie for the Assessment of Social Cognition [MASC]) were evaluated. The e-Motions test demonstrated high global internal consistency (KR-20 = 0.86) and good test–retest reliability (ICC₂,₁ = 0.73). Scores showed positive moderate correlations with both lower-level mentalizing tests (RME: ρ = 0.44; Ekman-60F: ρ = 0.48) and higher-level mentalizing test (MASC: ρ = 0.57). Discriminative power was strong for distinguishing healthy participants from individuals with schizophrenia (AUC = 0.89) and ASD (AUC = 0.79).

Conclusions

e-Motions test is the first AI-based test created ad hoc for awake brain mapping. Its good internal consistency and significant correlation with low-level and high-level mentalizing tests make this tool a novel, ecological and promising way to identify critical regions involved in social cognition during awake brain mapping. Future studies should be performed to demonstrate its validity preserving this complex higher-order cognitive construct during and after brain tumor surgery.

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.