氨基苯甲酰胺和醛介导的苯并噻唑二嗪1,1-二氧化物衍生物的温和合成

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2025-07-31 DOI:10.1002/jhet.70049

Dongxiao He, Yu Zhou, Yue Wu, Qiuzhu Chen, Wei Li, Wei Wang, Zongjie Gan

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引用次数: 0

摘要

以分子碘（I2）为唯一氧化剂，以市售醛类和2-氨基苯磺酰胺为原料，建立了一种无过渡金属、环境友好的氧化环化方法，用于一锅法合成苯并噻二嗪1,1-二氧化衍生物。该方法的特点是底物范围广，操作简单，易于获得一系列苯并噻嗪1,1-二氧化衍生物，收率中等至较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

I2-Mediated Mild Synthesis of Benzothiadiazine 1,1-Dioxide Derivatives From Aminobenzamides and Aldehydes

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I2-Mediated Mild Synthesis of Benzothiadiazine 1,1-Dioxide Derivatives From Aminobenzamides and Aldehydes

An environmentally benign and transition metal-free oxidative cyclization method has been developed for the one-pot synthesis of benzothiadiazine 1,1-dioxide derivatives, utilizing molecular iodine (I₂) as the sole oxidant from commercially available aldehydes and 2-aminobenzenesulfonamides. The protocol features a wide substrate scope and simple operation, providing easy access to a range of benzothiadiazine 1,1-dioxide derivatives in moderate to good yields.

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.