Recent Advances in the Pharmacological Applications of 1,3,4-Oxadiazole Derivatives: A Comprehensive Review

Oxadiazoles have gathered significant courtesy in recent years due to their diverse pharmacological activities and synthetic versatility. Despite the extensive selection of heterocyclic derivatives, 1,3,4-oxadiazole has been essential to medical chemistry. Many synthesized compounds containing the oxadiazole nucleus are employed in antibacterial, antifungal, analgesic, anticonvulsant, HIV activity, antiinflammatory, plant growth-promoting agents, and herbicidal characteristics that have been investigated for derivatives of 1,3,4-oxadiazole, which have been essential in the development of pharmaceutically significant compounds. Inspired by these findings, scientists from all around the world are working to synthesize novel heterocycles with an oxadiazole moiety in the hopes of enhancing their medicinal and biological potential. The insights presented aim to act as a valuable resource for researchers and chemists involved in the synthesis of novel therapeutic representatives based on 1,3,4-oxadiazole scaffolds. In an effort to generate fresh ideas for the creation of more potent and less hazardous 1,3,4-oxadiazole-based scaffolds, ideally, this review would be very beneficial.