咪唑[1,2- A]吲哚、2,3-二氢- 1h -咪唑[1,2- A]-吲哚和苯并[4,5]咪唑[1,2- A]吲哚衍生物的合成方法综述

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2025-08-12 DOI:10.1002/jhet.70026

Elizabeth J. Diana, Thomas V. Mathew

{"title":"咪唑[1,2- A]吲哚、2,3-二氢- 1h -咪唑[1,2- A]-吲哚和苯并[4,5]咪唑[1,2- A]吲哚衍生物的合成方法综述","authors":"Elizabeth J. Diana, Thomas V. Mathew","doi":"10.1002/jhet.70026","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Imidazo[1,2-a]indoles, 2,3-dihydro-1<i>H</i>-imidazo[1,2-a]-indoles and benzo[4,5]imidazo[1,2-a]indoles are rare yet valuable classes of nitrogen-containing heterocycles, offering diverse applications in pharmaceutical development and advanced materials research. Despite their potential medicinal applications, efficient synthesis methods for these substances remain limited. This review provides an in-depth analysis of emerging synthetic approaches for imidazo[1,2-a]indoles and benzo[4,5]imidazo[1,2-a]indoles, including metal-catalyzed and metal-free methods, as well as metal-catalyzed synthesis of 2,3-dihydro-1<i>H</i>-imidazo[1,2-a]indoles, offering valuable insights into effective synthetic strategies.</p>\n </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"62 10","pages":"1087-1103"},"PeriodicalIF":2.0000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthetic Approaches to Imidazo[1,2-a]indole,2,3-dihydro-1H-imidazo[1,2-a]-indoles and Benzo[4,5]imidazo[1,2-a]indole Derivatives: A Comprehensive Review\",\"authors\":\"Elizabeth J. Diana, Thomas V. Mathew\",\"doi\":\"10.1002/jhet.70026\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Imidazo[1,2-a]indoles, 2,3-dihydro-1<i>H</i>-imidazo[1,2-a]-indoles and benzo[4,5]imidazo[1,2-a]indoles are rare yet valuable classes of nitrogen-containing heterocycles, offering diverse applications in pharmaceutical development and advanced materials research. Despite their potential medicinal applications, efficient synthesis methods for these substances remain limited. This review provides an in-depth analysis of emerging synthetic approaches for imidazo[1,2-a]indoles and benzo[4,5]imidazo[1,2-a]indoles, including metal-catalyzed and metal-free methods, as well as metal-catalyzed synthesis of 2,3-dihydro-1<i>H</i>-imidazo[1,2-a]indoles, offering valuable insights into effective synthetic strategies.</p>\\n </div>\",\"PeriodicalId\":194,\"journal\":{\"name\":\"Journal of Heterocyclic Chemistry\",\"volume\":\"62 10\",\"pages\":\"1087-1103\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Heterocyclic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jhet.70026\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heterocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jhet.70026","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

咪唑[1,2-a]吲哚、2,3-二氢-1 - h -咪唑[1,2-a]-吲哚和苯并[4,5]咪唑[1,2-a]吲哚是一类稀有但有价值的含氮杂环化合物，在药物开发和先进材料研究中有着广泛的应用。尽管这些物质具有潜在的药用价值，但有效的合成方法仍然有限。本文综述了咪唑[1,2-a]吲哚和苯并[4,5]咪唑[1,2-a]吲哚的新合成方法，包括金属催化法和无金属法，以及金属催化合成2,3-二氢- 1h -咪唑[1,2-a]吲哚的方法，为有效的合成策略提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthetic Approaches to Imidazo[1,2-a]indole,2,3-dihydro-1H-imidazo[1,2-a]-indoles and Benzo[4,5]imidazo[1,2-a]indole Derivatives: A Comprehensive Review

查看原文本刊更多论文

Synthetic Approaches to Imidazo[1,2-a]indole,2,3-dihydro-1H-imidazo[1,2-a]-indoles and Benzo[4,5]imidazo[1,2-a]indole Derivatives: A Comprehensive Review

Imidazo[1,2-a]indoles, 2,3-dihydro-1H-imidazo[1,2-a]-indoles and benzo[4,5]imidazo[1,2-a]indoles are rare yet valuable classes of nitrogen-containing heterocycles, offering diverse applications in pharmaceutical development and advanced materials research. Despite their potential medicinal applications, efficient synthesis methods for these substances remain limited. This review provides an in-depth analysis of emerging synthetic approaches for imidazo[1,2-a]indoles and benzo[4,5]imidazo[1,2-a]indoles, including metal-catalyzed and metal-free methods, as well as metal-catalyzed synthesis of 2,3-dihydro-1H-imidazo[1,2-a]indoles, offering valuable insights into effective synthetic strategies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.