{"title":"用于表面增强光学生物传感的微/纳米材料","authors":"Jie Zhao, Xinyi Liu, Xujiang Yu, Wanwan Li","doi":"10.1002/adom.202501098","DOIUrl":null,"url":null,"abstract":"<p>Optical biosensors are pivotal for their stability and high throughput, but their sensitivity often hinges on optical signal strength. Thanks to the combination of plasmonic nanostructures and spectroscopy, surface-enhanced spectroscopy (SES) has emerged as a powerful tool for identifying and characterizing trace molecular species with ultrahigh sensitivity. This technique holds broad application prospects in the field of optical biosensors, including surface-enhanced fluorescence (SEF), surface-enhanced Raman scattering (SERS), and surface-enhanced infrared absorption (SEIRA), which significantly improve the interaction intensity between photons and materials. This review elaborates on SES from the perspective of the combined system of SEF, SERS, and SEIRA, and summarizes the mechanism, micro-/nanomaterials structural design principles, and applications. A comprehensive review of the mechanisms from electromagnetic and chemical perspectives is provided. Reasonable micro/nanomaterial design strategies are then discussed to customize hot spots for different platforms with optimal enhancement. The review aims to emphasize the significant impact of micro-/nanomaterials in surface-enhanced optical biosensing. Besides, the progress of surface-enhanced biosensors around immunoassays, DNA/RNA, and other biomolecules is summarized. Finally, the challenges and future directions of the field are outlined.</p>","PeriodicalId":116,"journal":{"name":"Advanced Optical Materials","volume":"13 28","pages":""},"PeriodicalIF":7.2000,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Micro-/Nanomaterials for Surface-Enhanced Optical Biosensing\",\"authors\":\"Jie Zhao, Xinyi Liu, Xujiang Yu, Wanwan Li\",\"doi\":\"10.1002/adom.202501098\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Optical biosensors are pivotal for their stability and high throughput, but their sensitivity often hinges on optical signal strength. Thanks to the combination of plasmonic nanostructures and spectroscopy, surface-enhanced spectroscopy (SES) has emerged as a powerful tool for identifying and characterizing trace molecular species with ultrahigh sensitivity. This technique holds broad application prospects in the field of optical biosensors, including surface-enhanced fluorescence (SEF), surface-enhanced Raman scattering (SERS), and surface-enhanced infrared absorption (SEIRA), which significantly improve the interaction intensity between photons and materials. This review elaborates on SES from the perspective of the combined system of SEF, SERS, and SEIRA, and summarizes the mechanism, micro-/nanomaterials structural design principles, and applications. A comprehensive review of the mechanisms from electromagnetic and chemical perspectives is provided. Reasonable micro/nanomaterial design strategies are then discussed to customize hot spots for different platforms with optimal enhancement. The review aims to emphasize the significant impact of micro-/nanomaterials in surface-enhanced optical biosensing. Besides, the progress of surface-enhanced biosensors around immunoassays, DNA/RNA, and other biomolecules is summarized. Finally, the challenges and future directions of the field are outlined.</p>\",\"PeriodicalId\":116,\"journal\":{\"name\":\"Advanced Optical Materials\",\"volume\":\"13 28\",\"pages\":\"\"},\"PeriodicalIF\":7.2000,\"publicationDate\":\"2025-08-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Optical Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adom.202501098\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Optical Materials","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adom.202501098","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Micro-/Nanomaterials for Surface-Enhanced Optical Biosensing
Optical biosensors are pivotal for their stability and high throughput, but their sensitivity often hinges on optical signal strength. Thanks to the combination of plasmonic nanostructures and spectroscopy, surface-enhanced spectroscopy (SES) has emerged as a powerful tool for identifying and characterizing trace molecular species with ultrahigh sensitivity. This technique holds broad application prospects in the field of optical biosensors, including surface-enhanced fluorescence (SEF), surface-enhanced Raman scattering (SERS), and surface-enhanced infrared absorption (SEIRA), which significantly improve the interaction intensity between photons and materials. This review elaborates on SES from the perspective of the combined system of SEF, SERS, and SEIRA, and summarizes the mechanism, micro-/nanomaterials structural design principles, and applications. A comprehensive review of the mechanisms from electromagnetic and chemical perspectives is provided. Reasonable micro/nanomaterial design strategies are then discussed to customize hot spots for different platforms with optimal enhancement. The review aims to emphasize the significant impact of micro-/nanomaterials in surface-enhanced optical biosensing. Besides, the progress of surface-enhanced biosensors around immunoassays, DNA/RNA, and other biomolecules is summarized. Finally, the challenges and future directions of the field are outlined.
期刊介绍:
Advanced Optical Materials, part of the esteemed Advanced portfolio, is a unique materials science journal concentrating on all facets of light-matter interactions. For over a decade, it has been the preferred optical materials journal for significant discoveries in photonics, plasmonics, metamaterials, and more. The Advanced portfolio from Wiley is a collection of globally respected, high-impact journals that disseminate the best science from established and emerging researchers, aiding them in fulfilling their mission and amplifying the reach of their scientific discoveries.