探索pd催化的烯类加氢反应：以丙二烯-1,2-二烯为重点的C（sp2）卤化物异丙烯化反应。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-30 DOI:10.1021/acs.orglett.5c03623

Louis Perrault,Romain Magny,Lucas Pagès,Rayane Mekerri,Clément Burgevin,Damien Cordeau,Emmanuel Roulland

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引用次数: 0

摘要

本文描述的操作简单的pd催化丙烯加氢反应使用HCO2Na，产生无害的CO2和卤化钠，并且在大多数情况下通过水/醚萃取分离出纯偶联产物。这种新的转变显示出广泛的C（sp2）卤化物范围，官能团耐受性，良好的收率和低成本的选择性氘化。0.10 mol %的Pd负载仍然有效，并进行了克级反应。该协议扩展到O-， N-， Si-和c -取代的烯，显示其通用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exploring Pd-Catalyzed Hydrocarbation of Allenes: Focusing on Propa-1,2-diene for the Isopropenylation of C(sp2) Halides.

The operatively simple Pd-catalyzed allene hydrocarbation described here uses HCO2Na and produces innocuous CO2 and sodium halide, and pure coupling products are isolated via water/ether extraction in most cases. This new transformation displays a broad C(sp2) halide scope, functional group tolerance, and good to excellent yields and allows inexpensive selective deuteration. Pd loadings of 0.10 mol % remain effective, and gram-scale reactions were conducted. The protocol extends to O-, N-, Si-, and C-substituted allenes, demonstrating its versatility.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.