钴催化非活化烯烃的分子内氟烷基羰基化。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-30 DOI:10.1021/acs.orglett.5c03691

Donghao Jiang,Zhudi He,Wei Li,Li-Jie Cheng

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引用次数: 0

摘要

一种钴催化的非活化烯烃分子内氟烷基羰基化方法已经被开发出来，使得高区域选择性合成氟烷基化γ-内酯的收率很高。反应条件温和，官能团耐受性好，可大规模进行反应。初步的机制研究支持自由基途径，其中阳离子酰基钴（IV）配合物被认为是关键中间体。

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Cobalt-Catalyzed Intramolecular Fluoroalkylative Carbonylation of Unactivated Alkenes.

A cobalt-catalyzed intramolecular fluoroalkylative carbonylation of unactivated alkenes has been developed, enabling the highly regioselective synthesis of fluoroalkylated γ-lactones in good yields. The mild reaction conditions exhibit good functional group tolerance, and the reaction can be performed on a large scale. Preliminary mechanistic investigations support a radical pathway in which a cationic acylcobalt(IV) complex is proposed as the key intermediate.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.