{"title":"心血管疾病中的乳酸酰化:目前的进展和前景。","authors":"Zhi-Mo Wang, Qing-Wen Yu, Cong Wang, Shu-Hui Wang, Pei Wang, Li-Rong Zhang, Sheng-Na Han","doi":"10.1161/JAHA.125.043801","DOIUrl":null,"url":null,"abstract":"<p><p>Emerging evidence suggests that epigenetic modifications, including lactylation-a recently identified posttranslational modification-may play a role in cardiovascular diseases (CVDs). Lactylation occurs in both histone and nonhistone proteins and has been implicated in processes, such as inflammation, lipid metabolism, and angiogenesis, which are relevant to CVD pathogenesis. However, the mechanistic links between lactylation and CVDs remain poorly understood, with most supporting evidence derived from preclinical studies. This review summarizes the current knowledge on lactylation, including its regulatory enzymes and potential functional roles in CVDs. While preliminary, these insights may inform future research directions for therapeutic strategies, early diagnostics, and disease prevention. Further validation in clinical studies is needed to establish the significance of lactylation in CVDs.</p>","PeriodicalId":54370,"journal":{"name":"Journal of the American Heart Association","volume":" ","pages":"e043801"},"PeriodicalIF":5.3000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lactylation in Cardiovascular Diseases: Current Progress and Perspectives.\",\"authors\":\"Zhi-Mo Wang, Qing-Wen Yu, Cong Wang, Shu-Hui Wang, Pei Wang, Li-Rong Zhang, Sheng-Na Han\",\"doi\":\"10.1161/JAHA.125.043801\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Emerging evidence suggests that epigenetic modifications, including lactylation-a recently identified posttranslational modification-may play a role in cardiovascular diseases (CVDs). Lactylation occurs in both histone and nonhistone proteins and has been implicated in processes, such as inflammation, lipid metabolism, and angiogenesis, which are relevant to CVD pathogenesis. However, the mechanistic links between lactylation and CVDs remain poorly understood, with most supporting evidence derived from preclinical studies. This review summarizes the current knowledge on lactylation, including its regulatory enzymes and potential functional roles in CVDs. While preliminary, these insights may inform future research directions for therapeutic strategies, early diagnostics, and disease prevention. Further validation in clinical studies is needed to establish the significance of lactylation in CVDs.</p>\",\"PeriodicalId\":54370,\"journal\":{\"name\":\"Journal of the American Heart Association\",\"volume\":\" \",\"pages\":\"e043801\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Heart Association\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1161/JAHA.125.043801\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Heart Association","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1161/JAHA.125.043801","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/30 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Lactylation in Cardiovascular Diseases: Current Progress and Perspectives.
Emerging evidence suggests that epigenetic modifications, including lactylation-a recently identified posttranslational modification-may play a role in cardiovascular diseases (CVDs). Lactylation occurs in both histone and nonhistone proteins and has been implicated in processes, such as inflammation, lipid metabolism, and angiogenesis, which are relevant to CVD pathogenesis. However, the mechanistic links between lactylation and CVDs remain poorly understood, with most supporting evidence derived from preclinical studies. This review summarizes the current knowledge on lactylation, including its regulatory enzymes and potential functional roles in CVDs. While preliminary, these insights may inform future research directions for therapeutic strategies, early diagnostics, and disease prevention. Further validation in clinical studies is needed to establish the significance of lactylation in CVDs.
期刊介绍:
As an Open Access journal, JAHA - Journal of the American Heart Association is rapidly and freely available, accelerating the translation of strong science into effective practice.
JAHA is an authoritative, peer-reviewed Open Access journal focusing on cardiovascular and cerebrovascular disease. JAHA provides a global forum for basic and clinical research and timely reviews on cardiovascular disease and stroke. As an Open Access journal, its content is free on publication to read, download, and share, accelerating the translation of strong science into effective practice.