中药抗乙型肝炎病毒作用:近二十年临床试验的启示。

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
Xue Feng, Nan-Nan Li, Gui-Jian Liu, Cheng An, Chao Liu
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引用次数: 0

摘要

乙型肝炎病毒(HBV)是一个严重的全球公共卫生问题。尽管核苷类药物和干扰素可以显著抑制HBV复制,但耐药和临床治愈率低等问题仍然存在。中药在中国广泛应用于慢性乙型肝炎(CHB)的治疗,具有抗炎、抗纤维化和肝脏保护作用;然而,关于其抗病毒作用的报道仍然不一致。我们检索了过去20年来中医药治疗慢性乙型肝炎的多中心临床研究和荟萃分析。结果显示,中药具有一定的抗hbv作用,与抗病毒药物联合使用可显著提高抗病毒疗效。结果表明,中药能最有效地促进血清HBV e抗原转化为阴性,其次是降低HBV DNA水平,促进HBV表面抗原丢失,改善慢性乙型肝炎的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-hepatitis B virus effects of traditional Chinese medicine: Learning from clinical trials in the past twenty years.

Hepatitis B virus (HBV) is a serious global public health concern. Although nucleoside drugs and interferons can significantly inhibit HBV replication, issues such as drug resistance and low clinical cure rates remain. Traditional Chinese medicine (TCM) is widely used in the treatment of chronic hepatitis B (CHB) in China, with anti-inflammatory, anti-fibrotic, and liver-protective effects; however, reports on its antiviral effects are still inconsistent. We retrieved multicenter clinical studies and meta-analyses of TCM treatment for CHB over the past two decades. The results revealed that TCM has a certain anti-HBV effect, and when combined with antiviral drugs, it can significantly improve antiviral efficacy. It was demonstrated that TCM most effectively promotes serum HBV e antigen conversion to negative, followed by the ability to reduce HBV DNA levels, facilitating HBV surface antigen loss, and improving the treatment of CHB.

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来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
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