{"title":"从肥胖患者收集的腹部脂肪组织样本的代谢组学——一项重要的综述。","authors":"Alina Jaroch","doi":"10.1007/s11010-025-05399-5","DOIUrl":null,"url":null,"abstract":"<p><p>Obesity is a multifactorial metabolic disorder characterized by excessive fat accumulation and associated with numerous health risks, including insulin resistance, cardiovascular disease, and metabolic syndrome. Adipose tissue, particularly subcutaneous (SAT) and visceral (VAT) fat, plays a central role in metabolic regulation, yet its biochemical properties and functions differ significantly. While metabolomics offers a promising approach to studying adipose tissue at a molecular level, significant methodological limitations and inconsistencies in study design undermine the reliability of current findings. Although VAT is frequently characterized by a pro-inflammatory and lipolytic metabolic profile, whereas SAT is more involved in lipid storage and insulin, these generalizations overlook important depot-specific variations and fail to address the heterogeneity within adipose tissue. This critical review evaluates existing metabolomic studies, identifying key discrepancies in lipid metabolism, energy homeostasis, and inflammation-related pathways across VAT and SAT. It highlights the need for improved standardization in metabolomic analyses, greater inclusion of diverse populations, and more robust longitudinal studies. By addressing these issues, future research can provide more precise insights into adipose tissue's role in obesity-related metabolic dysfunction and better inform clinical strategies for obesity management.</p>","PeriodicalId":18724,"journal":{"name":"Molecular and Cellular Biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Metabolomics of abdominal adipose tissue samples collected from patients with obesity - a critical review.\",\"authors\":\"Alina Jaroch\",\"doi\":\"10.1007/s11010-025-05399-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Obesity is a multifactorial metabolic disorder characterized by excessive fat accumulation and associated with numerous health risks, including insulin resistance, cardiovascular disease, and metabolic syndrome. Adipose tissue, particularly subcutaneous (SAT) and visceral (VAT) fat, plays a central role in metabolic regulation, yet its biochemical properties and functions differ significantly. While metabolomics offers a promising approach to studying adipose tissue at a molecular level, significant methodological limitations and inconsistencies in study design undermine the reliability of current findings. Although VAT is frequently characterized by a pro-inflammatory and lipolytic metabolic profile, whereas SAT is more involved in lipid storage and insulin, these generalizations overlook important depot-specific variations and fail to address the heterogeneity within adipose tissue. This critical review evaluates existing metabolomic studies, identifying key discrepancies in lipid metabolism, energy homeostasis, and inflammation-related pathways across VAT and SAT. It highlights the need for improved standardization in metabolomic analyses, greater inclusion of diverse populations, and more robust longitudinal studies. By addressing these issues, future research can provide more precise insights into adipose tissue's role in obesity-related metabolic dysfunction and better inform clinical strategies for obesity management.</p>\",\"PeriodicalId\":18724,\"journal\":{\"name\":\"Molecular and Cellular Biochemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular and Cellular Biochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s11010-025-05399-5\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and Cellular Biochemistry","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11010-025-05399-5","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Metabolomics of abdominal adipose tissue samples collected from patients with obesity - a critical review.
Obesity is a multifactorial metabolic disorder characterized by excessive fat accumulation and associated with numerous health risks, including insulin resistance, cardiovascular disease, and metabolic syndrome. Adipose tissue, particularly subcutaneous (SAT) and visceral (VAT) fat, plays a central role in metabolic regulation, yet its biochemical properties and functions differ significantly. While metabolomics offers a promising approach to studying adipose tissue at a molecular level, significant methodological limitations and inconsistencies in study design undermine the reliability of current findings. Although VAT is frequently characterized by a pro-inflammatory and lipolytic metabolic profile, whereas SAT is more involved in lipid storage and insulin, these generalizations overlook important depot-specific variations and fail to address the heterogeneity within adipose tissue. This critical review evaluates existing metabolomic studies, identifying key discrepancies in lipid metabolism, energy homeostasis, and inflammation-related pathways across VAT and SAT. It highlights the need for improved standardization in metabolomic analyses, greater inclusion of diverse populations, and more robust longitudinal studies. By addressing these issues, future research can provide more precise insights into adipose tissue's role in obesity-related metabolic dysfunction and better inform clinical strategies for obesity management.
期刊介绍:
Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell.
In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.