将HIV预防干预整合到广泛使用的中国男男性行为者地理社交应用程序中:单臂试验方案和重复横断面研究

IF 1.5 Q3 HEALTH CARE SCIENCES & SERVICES
Wenting Huang, Kunru Ning, Shi Hao Ernest Koh, Guodong Mi, Fei Yu, Yufen Liu, Daniel Stegmueller, Kimberly A Powers, Stefan Baral, Patrick S Sullivan, Aaron J Siegler
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引用次数: 0

摘要

背景:在中国,艾滋病毒对男男性行为者的影响不成比例。然而,在这一人群中,艾滋病毒预防服务的使用仍然有限,部分原因是担心隐私和性别身份的披露。这些问题可通过远程保健服务加以解决。目的:本研究旨在评估Blued+的可行性和可接受性,Blued+将HIV预防服务包整合到中国男男性行为者常用的地理社交网络应用程序中。方法:研究设计为Blued+干预的单臂试验,在男男性行为者中进行,使用重复的外部人群横断面调查进行比较。在初步研究中,研究人员从北京和成都招募了男性。在入组和第0个月(基线)进行为期3个月的标准护理期测量后,在第3、6、9和12个月进行为期12个月的干预期测量。在干预期间,参与者接受了增强版的Blued应用程序(Blued+),其中包括艾滋病毒检测,根据需要与护理联系,避孕套和安全套兼容润滑剂的选择,以及暴露前预防(PrEP)服务。PrEP通过应用程序内咨询和处方提供,然后在当地诊所进行实验室测试,并邮寄药物。在第0、6和12个月对北京和成都的男性进行了三次横断面调查,他们没有参加另一项艾滋病毒预防研究。这些参与者可以使用标准的Blued地理社交网络应用程序和当地的医疗服务。可行性的主要结局指标为家庭HIV检测和PrEP的接受情况。干预可接受性的主要结局指标为系统可用性量表。结果:2022年7月15日启动磨合期,2022年8月24日完成招聘。基线期于2022年11月结束,所有后续评估于2023年12月完成。在基线时,试点研究招募了423名参与者,横断面比较招募了1314名参与者。该试点的参与者年轻(平均年龄30岁,SD 7岁),受过教育(324/423,76.6%报告大学或更高学历),大多数(302/423,71.4%)报告在前3个月内进行了艾滋病毒检测。大多数参与者(404/ 423,95.5%)听说过PrEP,超过四分之一的人使用过PrEP(114/ 423,27%)。比较人群的参与者具有相似的社会人口学特征,报告前3个月的HIV检测(501/857,58.5%),PrEP意识(723/857,84.4%)和最近3个月的PrEP使用(182/857,15.4%)。结论:本初步研究将为Blued+干预的可行性和可接受性提供初步证据。研究结果将为未来的研究提供证据,为将预防平台嵌入已经广泛使用的应用程序奠定基础。如果观察到初步影响,未来的研究将包括干预措施的混合效果实施试验。试验注册:ClinicalTrials.gov NCT06647173;https://clinicaltrials.gov/study/NCT06647173.International注册报告标识符(irrid): DERR1-10.2196/69536。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrating a Combination HIV Prevention Intervention Into a Widely Used Geosocial App for Chinese Men Who Have Sex With Men: Protocol for a Single-Arm Pilot and Repeated Cross-Sectional Study.

Background: HIV disproportionately affects men who have sex with men in China. However, HIV prevention services use among this population remains limited, in part due to concerns of privacy and sexual identity disclosure. These concerns might be addressed through telehealth services.

Objective: This study was designed to assess the feasibility and acceptability of Blued+, which integrates an HIV prevention services package into a geosocial networking app commonly used by Chinese men who have sex with men.

Methods: The study design was a single-arm pilot of the Blued+ intervention among men who have sex with men, using repeated cross-sectional surveys of an external population for comparison. For the pilot study, men were recruited from Beijing and Chengdu. A 3-month standard-of-care period with measurement at enrollment and month 0 (baseline) was followed by a 12-month intervention period with measurement at months 3, 6, 9, and 12. During the intervention period, participants received the enhanced version of the Blued app (Blued+) with HIV testing, linkage to care as needed, choice of condoms and condom-compatible lubricants, and pre-exposure prophylaxis (PrEP) services. PrEP was provided through in-app counseling and prescription, followed by lab tests at local clinics and mailed medication. Three cross-sectional surveys in months 0, 6, and 12 were administered to men in Beijing and Chengdu who were not enrolled in another HIV prevention study. These participants had access to the standard Blued geosocial networking app and local health services. The primary outcome of feasibility was the uptake of home HIV testing and PrEP. The coprimary outcome of intervention acceptability was measured with the System Usability Scale.

Results: The run-in period was launched on July 15, 2022, with recruitment completed on August 24, 2022. The baseline period concluded in November 2022, and all follow-up assessments were completed by December 2023. At baseline, the pilot study enrolled 423 participants, and the cross-sectional comparison enrolled 1314 participants. Participants in the pilot were young (mean age 30, SD 7 years) and educated (324/423, 76.6% reported a college degree or higher), and most (302/423, 71.4%) reported HIV testing in the prior 3 months. Most participants (404/423, 95.5%) had heard of PrEP, and over a quarter had used PrEP (114/423, 27%). Participants in the comparison population had comparable sociodemographic characteristics, reporting HIV testing (501/857, 58.5%) in the prior 3 months, PrEP awareness (723/857, 84.4%), and PrEP use in the last 3 months (182/857, 15.4%).

Conclusions: This pilot study will provide preliminary evidence regarding the feasibility and acceptability of the Blued+ intervention. The study findings will provide evidence setting the foundation for future research that involves embedding prevention platforms into apps that are already widely used. If preliminary impact is observed, future research would include a hybrid effectiveness implementation trial of the intervention.

Trial registration: ClinicalTrials.gov NCT06647173; https://clinicaltrials.gov/study/NCT06647173.

International registered report identifier (irrid): DERR1-10.2196/69536.

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来源期刊
CiteScore
2.40
自引率
5.90%
发文量
414
审稿时长
12 weeks
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