{"title":"术前窦性心律患者接受心脏或主动脉手术后房颤的发生率和预测因素。","authors":"Norimasa Haijima, Mikihiko Kudo, Satoru Murata, Takuya Ono, Hideyuki Shimizu","doi":"10.1007/s00380-025-02610-x","DOIUrl":null,"url":null,"abstract":"<p><p>Postoperative atrial fibrillation (POAF) is frequent after cardiac or aortic surgery and is linked to adverse outcomes. We evaluated the incidence and independent predictors of POAF in patients with preoperative sinus rhythm. We conducted a single-center retrospective cohort study of 78 patients undergoing cardiac or aortic surgery (May 2022-December 2024). POAF during the index hospitalization was modeled using multivariable logistic regression with three prespecified predictors: transmitral early (E) to late (A) diastolic filling velocity ratio (E/A)(per + 1.0), CHADS₂ ≥ 2, and abnormal body mass index (BMI) (< 18.5 or ≥ 25.0 kg/m<sup>2</sup>). Model performance was summarized by AUC (DeLong 95% CI), Brier score, calibration metrics, and Akaike information criterion (AIC). POAF occurred in 49/78 patients (62.8%). Higher E/A independently predicted POAF (adjusted OR 19.38; 95% CI 3.92-141.87; p = 0.001), as did CHADS₂ ≥ 2 (adjusted OR 4.39; 95% CI 1.31-17.50; p = 0.024) and abnormal BMI (adjusted OR 5.08; 95% CI 1.51-20.44; p = 0.011). The model showed good discrimination (AUC 0.806; 95% CI 0.709-0.904) and acceptable calibration (Brier 0.168; Hosmer-Lemeshow p = 0.530 with g = 10; calibration slope 1.00; intercept 0.00). AIC was 93.50. In patients with preoperative sinus rhythm, higher E/A (continuous), CHADS₂ ≥ 2, and abnormal BMI independently predict POAF, with good model discrimination and calibration. Routine preoperative echocardiography combined with simple clinical indices may aid perioperative risk stratification.</p>","PeriodicalId":12940,"journal":{"name":"Heart and Vessels","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Incidence and predictors of postoperative atrial fibrillation in patients with preoperative sinus rhythm undergoing cardiac or aortic surgery.\",\"authors\":\"Norimasa Haijima, Mikihiko Kudo, Satoru Murata, Takuya Ono, Hideyuki Shimizu\",\"doi\":\"10.1007/s00380-025-02610-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Postoperative atrial fibrillation (POAF) is frequent after cardiac or aortic surgery and is linked to adverse outcomes. We evaluated the incidence and independent predictors of POAF in patients with preoperative sinus rhythm. We conducted a single-center retrospective cohort study of 78 patients undergoing cardiac or aortic surgery (May 2022-December 2024). POAF during the index hospitalization was modeled using multivariable logistic regression with three prespecified predictors: transmitral early (E) to late (A) diastolic filling velocity ratio (E/A)(per + 1.0), CHADS₂ ≥ 2, and abnormal body mass index (BMI) (< 18.5 or ≥ 25.0 kg/m<sup>2</sup>). Model performance was summarized by AUC (DeLong 95% CI), Brier score, calibration metrics, and Akaike information criterion (AIC). POAF occurred in 49/78 patients (62.8%). Higher E/A independently predicted POAF (adjusted OR 19.38; 95% CI 3.92-141.87; p = 0.001), as did CHADS₂ ≥ 2 (adjusted OR 4.39; 95% CI 1.31-17.50; p = 0.024) and abnormal BMI (adjusted OR 5.08; 95% CI 1.51-20.44; p = 0.011). The model showed good discrimination (AUC 0.806; 95% CI 0.709-0.904) and acceptable calibration (Brier 0.168; Hosmer-Lemeshow p = 0.530 with g = 10; calibration slope 1.00; intercept 0.00). AIC was 93.50. In patients with preoperative sinus rhythm, higher E/A (continuous), CHADS₂ ≥ 2, and abnormal BMI independently predict POAF, with good model discrimination and calibration. Routine preoperative echocardiography combined with simple clinical indices may aid perioperative risk stratification.</p>\",\"PeriodicalId\":12940,\"journal\":{\"name\":\"Heart and Vessels\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Heart and Vessels\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00380-025-02610-x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart and Vessels","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00380-025-02610-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
术后心房颤动(POAF)在心脏或主动脉手术后很常见,并与不良后果有关。我们评估了术前窦性心律患者POAF的发生率和独立预测因素。我们对78例接受心脏或主动脉手术的患者(2022年5月至2024年12月)进行了单中心回顾性队列研究。指数住院期间的POAF采用多变量logistic回归模型,具有三个预先指定的预测因子:传导早(E)至晚(A)舒张充盈速度比(E/A)(per + 1.0)、CHADS 2≥2和异常体重指数(BMI)(2)。通过AUC (DeLong 95% CI)、Brier评分、校准指标和赤池信息标准(Akaike information criterion, AIC)对模型的性能进行总结。78例患者中有49例(62.8%)发生POAF。较高的E/A独立预测POAF(校正OR 19.38; 95% CI 3.92-141.87; p = 0.001), CHADS 2≥2(校正OR 4.39; 95% CI 1.31-17.50; p = 0.024)和异常BMI(校正OR 5.08; 95% CI 1.51-20.44; p = 0.011)也是如此。该模型具有良好的判别性(AUC 0.806; 95% CI 0.709-0.904)和可接受的校准(Brier 0.168; Hosmer-Lemeshow p = 0.530, g = 10;校准斜率1.00;截距0.00)。AIC为93.50。术前窦性心律患者,较高的E/A(持续)、CHADS 2≥2、BMI异常独立预测POAF,具有良好的模型判别和校准。术前常规超声心动图结合简单的临床指标有助于围手术期危险分层。
Incidence and predictors of postoperative atrial fibrillation in patients with preoperative sinus rhythm undergoing cardiac or aortic surgery.
Postoperative atrial fibrillation (POAF) is frequent after cardiac or aortic surgery and is linked to adverse outcomes. We evaluated the incidence and independent predictors of POAF in patients with preoperative sinus rhythm. We conducted a single-center retrospective cohort study of 78 patients undergoing cardiac or aortic surgery (May 2022-December 2024). POAF during the index hospitalization was modeled using multivariable logistic regression with three prespecified predictors: transmitral early (E) to late (A) diastolic filling velocity ratio (E/A)(per + 1.0), CHADS₂ ≥ 2, and abnormal body mass index (BMI) (< 18.5 or ≥ 25.0 kg/m2). Model performance was summarized by AUC (DeLong 95% CI), Brier score, calibration metrics, and Akaike information criterion (AIC). POAF occurred in 49/78 patients (62.8%). Higher E/A independently predicted POAF (adjusted OR 19.38; 95% CI 3.92-141.87; p = 0.001), as did CHADS₂ ≥ 2 (adjusted OR 4.39; 95% CI 1.31-17.50; p = 0.024) and abnormal BMI (adjusted OR 5.08; 95% CI 1.51-20.44; p = 0.011). The model showed good discrimination (AUC 0.806; 95% CI 0.709-0.904) and acceptable calibration (Brier 0.168; Hosmer-Lemeshow p = 0.530 with g = 10; calibration slope 1.00; intercept 0.00). AIC was 93.50. In patients with preoperative sinus rhythm, higher E/A (continuous), CHADS₂ ≥ 2, and abnormal BMI independently predict POAF, with good model discrimination and calibration. Routine preoperative echocardiography combined with simple clinical indices may aid perioperative risk stratification.
期刊介绍:
Heart and Vessels is an English-language journal that provides a forum of original ideas, excellent methods, and fascinating techniques on cardiovascular disease fields. All papers submitted for publication are evaluated only with regard to scientific quality and relevance to the heart and vessels. Contributions from those engaged in practical medicine, as well as from those involved in basic research, are welcomed.