Ugur Kaplankaya, Erhan Onalan, Tugce Kaymaz, Burkay Yakar, Ruveyda Atilla, Aykut Bulu, Senanur Onalan Yıldırım, Mehmet Ferit Gursu, Emir Donder, Mustafa Hayırlıdağ
{"title":"血清三甲胺n-氧化物和脂多糖水平在幽门螺杆菌感染慢性胃炎发病机制中的作用。","authors":"Ugur Kaplankaya, Erhan Onalan, Tugce Kaymaz, Burkay Yakar, Ruveyda Atilla, Aykut Bulu, Senanur Onalan Yıldırım, Mehmet Ferit Gursu, Emir Donder, Mustafa Hayırlıdağ","doi":"10.1186/s12876-025-04272-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Helicobacter pylori (HP) infection can cause chronic, intense inflammation of the gastric mucosa, which can lead to stomach cancer. Trimethylamine N-oxide (TMAO) is a dietary metabolite that increases HP virulence and inflammatory process. In this study, we aimed to find out how serum TMAO, lipopolysaccharide (LPS) and pepsinogen levels are affected in patients with HP-induced chronic gastritis.</p><p><strong>Methods: </strong>Forty-five age- and sex-matched patients diagnosed with chronic gastritis caused by H. Pylori and 45 healthy controls were included in this cross-sectional study. The diagnosis of H. Pylori-associated chronic gastritis was confirmed by endoscopy and biopsy. Serum TMAO, LPS, pepsinogen 1 and pepsinogen 2 levels were studied by the ELISA method.</p><p><strong>Results: </strong>Serum TMAO level of patients with HP gastritis was 48.61 (2.29-120.66) and that of the control group was 7.89 (1.22-76.40). Serum TMAO levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p < 0.001). Serum LPS levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.008). Serum pepsinogen 1 levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.001).</p><p><strong>Conclusion: </strong>The present study found elevated serum TMAO, LPS and pepsinogen 1 levels in patients with H. Pylori gastritis. These serum markers can be used as a non-invasive method in the evaluation of chronic gastritis infected with H. pylori.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"686"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482537/pdf/","citationCount":"0","resultStr":"{\"title\":\"The role of serum trimethylamine n-oxide and lipopolysaccharide levels in the pathogenesis of chronic gastritis infected with Helicobacter pylori.\",\"authors\":\"Ugur Kaplankaya, Erhan Onalan, Tugce Kaymaz, Burkay Yakar, Ruveyda Atilla, Aykut Bulu, Senanur Onalan Yıldırım, Mehmet Ferit Gursu, Emir Donder, Mustafa Hayırlıdağ\",\"doi\":\"10.1186/s12876-025-04272-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Helicobacter pylori (HP) infection can cause chronic, intense inflammation of the gastric mucosa, which can lead to stomach cancer. Trimethylamine N-oxide (TMAO) is a dietary metabolite that increases HP virulence and inflammatory process. In this study, we aimed to find out how serum TMAO, lipopolysaccharide (LPS) and pepsinogen levels are affected in patients with HP-induced chronic gastritis.</p><p><strong>Methods: </strong>Forty-five age- and sex-matched patients diagnosed with chronic gastritis caused by H. Pylori and 45 healthy controls were included in this cross-sectional study. The diagnosis of H. Pylori-associated chronic gastritis was confirmed by endoscopy and biopsy. Serum TMAO, LPS, pepsinogen 1 and pepsinogen 2 levels were studied by the ELISA method.</p><p><strong>Results: </strong>Serum TMAO level of patients with HP gastritis was 48.61 (2.29-120.66) and that of the control group was 7.89 (1.22-76.40). Serum TMAO levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p < 0.001). Serum LPS levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.008). Serum pepsinogen 1 levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.001).</p><p><strong>Conclusion: </strong>The present study found elevated serum TMAO, LPS and pepsinogen 1 levels in patients with H. Pylori gastritis. These serum markers can be used as a non-invasive method in the evaluation of chronic gastritis infected with H. pylori.</p>\",\"PeriodicalId\":9129,\"journal\":{\"name\":\"BMC Gastroenterology\",\"volume\":\"25 1\",\"pages\":\"686\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482537/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Gastroenterology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12876-025-04272-5\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12876-025-04272-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
The role of serum trimethylamine n-oxide and lipopolysaccharide levels in the pathogenesis of chronic gastritis infected with Helicobacter pylori.
Background: Helicobacter pylori (HP) infection can cause chronic, intense inflammation of the gastric mucosa, which can lead to stomach cancer. Trimethylamine N-oxide (TMAO) is a dietary metabolite that increases HP virulence and inflammatory process. In this study, we aimed to find out how serum TMAO, lipopolysaccharide (LPS) and pepsinogen levels are affected in patients with HP-induced chronic gastritis.
Methods: Forty-five age- and sex-matched patients diagnosed with chronic gastritis caused by H. Pylori and 45 healthy controls were included in this cross-sectional study. The diagnosis of H. Pylori-associated chronic gastritis was confirmed by endoscopy and biopsy. Serum TMAO, LPS, pepsinogen 1 and pepsinogen 2 levels were studied by the ELISA method.
Results: Serum TMAO level of patients with HP gastritis was 48.61 (2.29-120.66) and that of the control group was 7.89 (1.22-76.40). Serum TMAO levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p < 0.001). Serum LPS levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.008). Serum pepsinogen 1 levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.001).
Conclusion: The present study found elevated serum TMAO, LPS and pepsinogen 1 levels in patients with H. Pylori gastritis. These serum markers can be used as a non-invasive method in the evaluation of chronic gastritis infected with H. pylori.
期刊介绍：
BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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