Sharon Pradeeptha, Magdalenal Robert, Anish Sam, Merin Abraham
{"title":"汞中毒表现为不受控制的高血压在两个儿童由于使用补充和替代药物。","authors":"Sharon Pradeeptha, Magdalenal Robert, Anish Sam, Merin Abraham","doi":"10.1136/bcr-2025-265318","DOIUrl":null,"url":null,"abstract":"<p><p>Two children aged <5 years presented with paraesthesias, limb pain, behavioural disturbances, weight loss and poor sleep for 2.5 months and had hypertension on examination.Extensive evaluation for aetiologies of hypertension, including catecholamine-secreting and neural crest tumours, cardiac, endocrine and renal causes, was inconclusive.History subsequently revealed the use of alternative Indian medicine in both children. Heavy metal toxicity was suspected and was confirmed with elevated 24-hour urinary mercury levels. Both children responded well to chelation therapy with dimercaprol and had resolution of symptoms on follow-up.These two cases highlight that heavy metal toxicity in children is an evolving health concern of global importance. Hence, knowledge about the presence of heavy metals as an ingredient in some alternative medicines, seeking history about their usage and suspecting the varied clinical manifestations of heavy metal toxicity is essential while evaluating a child with uncontrolled hypertension.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"18 9","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mercury toxicity presenting as uncontrolled hypertension in two children due to the use of complementary and alternative medicine.\",\"authors\":\"Sharon Pradeeptha, Magdalenal Robert, Anish Sam, Merin Abraham\",\"doi\":\"10.1136/bcr-2025-265318\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Two children aged <5 years presented with paraesthesias, limb pain, behavioural disturbances, weight loss and poor sleep for 2.5 months and had hypertension on examination.Extensive evaluation for aetiologies of hypertension, including catecholamine-secreting and neural crest tumours, cardiac, endocrine and renal causes, was inconclusive.History subsequently revealed the use of alternative Indian medicine in both children. Heavy metal toxicity was suspected and was confirmed with elevated 24-hour urinary mercury levels. Both children responded well to chelation therapy with dimercaprol and had resolution of symptoms on follow-up.These two cases highlight that heavy metal toxicity in children is an evolving health concern of global importance. Hence, knowledge about the presence of heavy metals as an ingredient in some alternative medicines, seeking history about their usage and suspecting the varied clinical manifestations of heavy metal toxicity is essential while evaluating a child with uncontrolled hypertension.</p>\",\"PeriodicalId\":9080,\"journal\":{\"name\":\"BMJ Case Reports\",\"volume\":\"18 9\",\"pages\":\"\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMJ Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/bcr-2025-265318\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/bcr-2025-265318","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Mercury toxicity presenting as uncontrolled hypertension in two children due to the use of complementary and alternative medicine.
Two children aged <5 years presented with paraesthesias, limb pain, behavioural disturbances, weight loss and poor sleep for 2.5 months and had hypertension on examination.Extensive evaluation for aetiologies of hypertension, including catecholamine-secreting and neural crest tumours, cardiac, endocrine and renal causes, was inconclusive.History subsequently revealed the use of alternative Indian medicine in both children. Heavy metal toxicity was suspected and was confirmed with elevated 24-hour urinary mercury levels. Both children responded well to chelation therapy with dimercaprol and had resolution of symptoms on follow-up.These two cases highlight that heavy metal toxicity in children is an evolving health concern of global importance. Hence, knowledge about the presence of heavy metals as an ingredient in some alternative medicines, seeking history about their usage and suspecting the varied clinical manifestations of heavy metal toxicity is essential while evaluating a child with uncontrolled hypertension.
期刊介绍:
BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.