乙酰胆碱及其受体在肿瘤免疫调节中的作用：机制和潜在的治疗靶点

IF 33.9 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-09-30 DOI:10.1186/s12943-025-02441-4

Chunyu Zhang, Xiangdong Guo, Yanan Wang, Shuo Zhang, Zhihua Wang

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引用次数: 0

摘要

乙酰胆碱（Acetylcholine, ACh）是一种重要的神经递质，近年来因其在肿瘤免疫调节中的多功能作用而受到关注。ACh通过将神经元丢失与烟碱和毒蕈碱受体结合，直接促进肿瘤细胞的增殖和迁移，同时调节免疫细胞功能，从而影响肿瘤微环境。此外，乙酰胆碱在肿瘤血管生成和基质重塑中起重要作用。最近的研究表明，乙酰胆碱调节剂与免疫检查点抑制剂和其他疗法联合使用可以提高治疗效果并克服耐药性。本文综述了乙酰胆碱在肿瘤免疫调节中的研究进展，探讨了其潜在机制和临床潜力，为制定个性化治疗策略提供了理论依据。

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The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets

Acetylcholine (ACh) is an essential neurotransmitter that has recently gained attention for its multifunctional role in tumor immune regulation. By binding neuronal loss to nicotinic and muscarinic receptors, ACh directly promotes tumor cell proliferation and migration while modulating immune cell functions, thereby influencing the tumor microenvironment. Additionally, ACh plays a crucial role in tumor angiogenesis and stromal remodeling. Recent studies suggest that combining ACh modulators with immune checkpoint inhibitors and other therapies may improve treatment efficacy and overcome resistance. This review highlights current research developments regarding ACh in tumor immune regulation, explores its underlying mechanisms and clinical potential, and provides a theoretical basis for developing personalized therapeutic strategies.

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.