儿童生长激素治疗的历史和现状。

IF 3.3 3区医学 Q1 PEDIATRICS

Pediatric Drugs Pub Date : 2025-09-29 DOI:10.1007/s40272-025-00721-6

Camila C Luz, Paulo F Collett-Solberg

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引用次数: 0

摘要

生长激素（GH）用于治疗严重的生长激素缺乏症已有60多年的历史，其他适应症依赖于国家医学协会和政府机构的批准。从从人脑垂体中提取生长激素到重组激素技术，从使用小瓶和注射器到使用更先进的设备，生长激素制剂已经发生了许多变化，以提高安全性、顺应性和有效性。坚持治疗一直被强调为治疗成功的关键；允许每周管理的新仓库准备在这方面具有优势。本文综述了生长激素的使用历史，并对新的每周给药产品进行了分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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History and Current Status of Growth Hormone Treatment in Children.

Growth hormone (GH) has been used to treat severe GH deficiency for more than 60 years, with other indications dependent upon approval from national medical societies and governmental agencies. Many changes in GH preparations have been made to improve safety, compliance, and efficacy, from the extraction of GH from human pituitary glands to recombinant hormone technology and from the use of vials and syringes to the use of more advanced devices. Adherence to treatment has always been highlighted as a key point in the success of treatment; new depot preparations permitting weekly administration have advantages in this regard. This review summarizes the history of GH use and provides an analysis of the new weekly administration products.

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来源期刊

Pediatric Drugs PEDIATRICS-PHARMACOLOGY & PHARMACY

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pediatric Drugs promotes the optimization and advancement of all aspects of pharmacotherapy for healthcare professionals interested in pediatric drug therapy (including vaccines). The program of review and original research articles provides healthcare decision makers with clinically applicable knowledge on issues relevant to drug therapy in all areas of neonatology and the care of children and adolescents. The Journal includes: -overviews of contentious or emerging issues. -comprehensive narrative reviews of topics relating to the effective and safe management of drug therapy through all stages of pediatric development. -practical reviews covering optimum drug management of specific clinical situations. -systematic reviews that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. -Adis Drug Reviews of the properties and place in therapy of both newer and established drugs in the pediatric population. -original research articles reporting the results of well-designed studies with a strong link to clinical practice, such as clinical pharmacodynamic and pharmacokinetic studies, clinical trials, meta-analyses, outcomes research, and pharmacoeconomic and pharmacoepidemiological studies. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in Pediatric Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.