Abigail Pajulas, Jonathan T Sims, Eric P Hanson, Andrew C Vendel
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引用次数: 0
摘要
受体相互作用蛋白激酶1 （Receptor-interacting protein kinase 1, RIPK1）调节细胞死亡和存活途径，是治疗多种自身免疫、炎症和神经退行性疾病的有希望的治疗靶点，在炎症、细胞凋亡和坏死性坏死中发挥重要作用。在这篇综述中，我们描述了最近的见解，有助于阐明依赖于RIPK1的信号通路的分子机制，重点是它的支架功能和激酶活性。我们强调RIPK1的细胞类型特异性作用，描述其在坏死下垂、免疫细胞调节和组织特异性反应中的作用。最后，我们提出了RIPK1在自身免疫性疾病和炎症性疾病中的相关性，同时强调了RIPK1靶向治疗的临床前景。总之，本综述旨在介绍有关RIPK1信号的最新发现，并讨论其作为疾病治疗靶点的潜力。
RIPK1 signaling pathways: implications for autoimmune and neuroinflammatory diseases.
Receptor-interacting protein kinase 1 (RIPK1), which regulates cell death and survival pathways, is a promising therapeutic target for the treatment of several autoimmune, inflammatory, and neurodegenerative diseases, having important roles in inflammation, apoptosis, and necroptosis. In this review, we describe recent insights that help elucidate the molecular mechanisms of signaling pathways reliant on RIPK1, focusing on its scaffolding function and kinase activity. We emphasize the cell type-specific effects of RIPK1, characterizing its role in necroptosis, immune cell regulation, and tissue-specific responses. Lastly, we present the relevance of RIPK1 in autoimmune and inflammatory diseases, while highlighting the clinical landscape for RIPK1-targeting therapies. All together, this review aims to present recent findings pertaining to RIPK1 signaling and discuss its potential as a therapeutic target in diseases.
期刊介绍：
Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.
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