Ana Elvira Zacapala-Gómez, Gabriela Hernández-Galicia, Francisco Israel Torres-Rojas, Christian Johana Baños-Hernández, Julio Ortiz-Ortiz, Hilda Jiménez-Wences, Gabriela Elizabeth Campos-Viguri, Verónica Antonio-Véjar, Judit Alarcón-Millán, Eric Genaro Salmerón-Bárcenas
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引用次数: 0
摘要
背景：宫颈癌（CC）在全球女性发病率和死亡率中排名第三。Let-7c是一种肿瘤抑制miRNA，其在CC中的作用研究甚少。runt相关转录因子1 （RUNX1）在多种人类癌症中上调，如结直肠癌。它是一种促进结直肠癌细胞增殖、转移、化疗抵抗和血管生成的转录因子。在这项研究中，我们进行了生物信息学分析，以了解Let-7c和RUNX1如何参与CC的发展。方法：我们使用来自GEO， km -绘图仪，miRPathDB和Enrich数据库的GSE和TCGA数据集对CC中的Let-7c进行了生物信息学分析。然后，我们利用来自OncoDB、CISTROME、ExPASy、Alibaba、ALGGEN、ENCODE、IGV、GEO、KM-plotter和DiseaseMeth数据库的TCGA、GSE和HPA数据集对RUNX1在CC中的作用进行了全面分析。结果：我们发现Let-7c在CC中的表达降低，有趣的是，我们发现了一个名为RUNX1的转录因子，作为Let-7c的潜在靶点。结论：Let-7c/RUNX1轴促进CC的发生。
Let-7c/RUNX1 Axis Promotes Cervical Cancer: A Bioinformatic Analysis.
Background: Cervical cancer (CC) ranks as the third most common cancer in incidence and mortality in females worldwide. Let-7c is a tumor suppressor miRNA, and its role has been little studied in CC. Runt-related transcription factor 1 (RUNX1) is upregulated in several human cancers, such as colorectal cancer. It is a transcription factor that promotes cell proliferation, metastasis, chemotherapy resistance and angiogenesis in colorectal cancer. In this study, we performed a bioinformatic analysis to understand how Let-7c and RUNX1 are involved in the development of CC.
Methods: We performed a bioinformatic analysis of Let-7c in CC using GSE and TCGA datasets from GEO, KM-plotter, miRPathDB and Enrich databases. Then, we conducted a comprehensive analysis of RUNX1's role in CC using TCGA, GSE and HPA datasets from OncoDB, CISTROME, ExPASy, Alibaba, ALGGEN, ENCODE, IGV, GEO, KM-plotter and DiseaseMeth databases.
Results: We found that Let-7c expression is decreased in CC. Interestingly, we identified a transcription factor known as RUNX1, as a potential target of Let-7c. Finally, we suggest that RUNX1 could regulate the expression of several genes, promoting CC.
期刊介绍：
Current Issues in Molecular Biology (CIMB) is a peer-reviewed journal publishing review articles and minireviews in all areas of molecular biology and microbiology. Submitted articles are subject to an Article Processing Charge (APC) and are open access immediately upon publication. All manuscripts undergo a peer-review process.
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