银屑病的心脏:心血管改变和常见的炎症机制。

IF 2.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Elpidio Santillo, Luciano Marini, Lucio Cardinali
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引用次数: 0

摘要

简介:本综述旨在探讨牛皮癣与心血管疾病(CVD)之间的共同病理生理机制,特别强调牛皮癣患者的心电图和超声心动图改变。方法:对1980年1月至2025年6月期间发表的研究进行PubMed和谷歌Scholar的综合检索。检索包括临床试验、观察性研究、综述和荟萃分析。结果:银屑病的发病机制与CVD有几个关键特征,特别是全身性炎症和内皮功能障碍。银屑病患者经常表现为心电图异常,如心律失常,包括心房颤动(AF)和心脏结构性改变,如左室舒张功能障碍。即使在没有临床上明显的心脏病的情况下,也经常观察到这些心血管变化。讨论:牛皮癣显著增加心血管风险,即使在没有明显CVD的患者中也是如此。慢性炎症、内皮功能障碍和代谢紊乱是导致这些个体心血管风险增加的关键因素。此外,银屑病关节炎的存在可能加剧这些关联,突出了该疾病的多面性。结论:早期发现和处理银屑病患者的心血管改变对减轻其长期心血管负担至关重要。靶向共同的炎症途径有望作为一种治疗方法来改善这一患者群体的皮肤病和心血管健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Heart of Psoriasis: Cardiovascular Alterations and Common Inflammatory Mechanisms.

Introduction: This mini-review aims to investigate the shared pathophysiological mechanisms linking psoriasis to cardiovascular disease (CVD), with a particular emphasis on electrocardiographic and echocardiographic alterations in individuals affected by psoriasis.

Methods: A comprehensive search of PubMed and Google Scholar was conducted for studies published between January 1980 and June 2025. The search included clinical trials, observational studies, reviews, and meta-analyses.

Results: The pathogenesis of psoriasis shares several key features with CVD, particularly systemic inflammation and endothelial dysfunction. Psoriasis patients frequently exhibit electrocardiographic abnormalities, such as arrhythmias, including atrial fibrillation (AF), and structural heart changes, such as left ventricular diastolic dysfunction. These cardiovascular changes are often observed even in the absence of clinically evident heart disease.

Discussion: Psoriasis significantly contributes to cardiovascular risk, even in patients without manifest CVD. Chronic inflammation, endothelial dysfunction, and metabolic disturbances are key factors contributing to the increased cardiovascular risk observed in these individuals. Furthermore, the presence of psoriatic arthritis may exacerbate these associations, highlighting the multifaceted nature of the disease.

Conclusion: Early detection and management of cardiovascular alterations in patients with psoriasis are essential for mitigating their long-term cardiovascular burden. Targeting shared inflammatory pathways holds promise as a therapeutic approach to improve both dermatological and cardiovascular health in this patient population.

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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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