{"title":"银屑病的心脏:心血管改变和常见的炎症机制。","authors":"Elpidio Santillo, Luciano Marini, Lucio Cardinali","doi":"10.2174/011573403X412277250911072530","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This mini-review aims to investigate the shared pathophysiological mechanisms linking psoriasis to cardiovascular disease (CVD), with a particular emphasis on electrocardiographic and echocardiographic alterations in individuals affected by psoriasis.</p><p><strong>Methods: </strong>A comprehensive search of PubMed and Google Scholar was conducted for studies published between January 1980 and June 2025. The search included clinical trials, observational studies, reviews, and meta-analyses.</p><p><strong>Results: </strong>The pathogenesis of psoriasis shares several key features with CVD, particularly systemic inflammation and endothelial dysfunction. Psoriasis patients frequently exhibit electrocardiographic abnormalities, such as arrhythmias, including atrial fibrillation (AF), and structural heart changes, such as left ventricular diastolic dysfunction. These cardiovascular changes are often observed even in the absence of clinically evident heart disease.</p><p><strong>Discussion: </strong>Psoriasis significantly contributes to cardiovascular risk, even in patients without manifest CVD. Chronic inflammation, endothelial dysfunction, and metabolic disturbances are key factors contributing to the increased cardiovascular risk observed in these individuals. Furthermore, the presence of psoriatic arthritis may exacerbate these associations, highlighting the multifaceted nature of the disease.</p><p><strong>Conclusion: </strong>Early detection and management of cardiovascular alterations in patients with psoriasis are essential for mitigating their long-term cardiovascular burden. Targeting shared inflammatory pathways holds promise as a therapeutic approach to improve both dermatological and cardiovascular health in this patient population.</p>","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Heart of Psoriasis: Cardiovascular Alterations and Common Inflammatory Mechanisms.\",\"authors\":\"Elpidio Santillo, Luciano Marini, Lucio Cardinali\",\"doi\":\"10.2174/011573403X412277250911072530\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This mini-review aims to investigate the shared pathophysiological mechanisms linking psoriasis to cardiovascular disease (CVD), with a particular emphasis on electrocardiographic and echocardiographic alterations in individuals affected by psoriasis.</p><p><strong>Methods: </strong>A comprehensive search of PubMed and Google Scholar was conducted for studies published between January 1980 and June 2025. The search included clinical trials, observational studies, reviews, and meta-analyses.</p><p><strong>Results: </strong>The pathogenesis of psoriasis shares several key features with CVD, particularly systemic inflammation and endothelial dysfunction. Psoriasis patients frequently exhibit electrocardiographic abnormalities, such as arrhythmias, including atrial fibrillation (AF), and structural heart changes, such as left ventricular diastolic dysfunction. These cardiovascular changes are often observed even in the absence of clinically evident heart disease.</p><p><strong>Discussion: </strong>Psoriasis significantly contributes to cardiovascular risk, even in patients without manifest CVD. Chronic inflammation, endothelial dysfunction, and metabolic disturbances are key factors contributing to the increased cardiovascular risk observed in these individuals. Furthermore, the presence of psoriatic arthritis may exacerbate these associations, highlighting the multifaceted nature of the disease.</p><p><strong>Conclusion: </strong>Early detection and management of cardiovascular alterations in patients with psoriasis are essential for mitigating their long-term cardiovascular burden. Targeting shared inflammatory pathways holds promise as a therapeutic approach to improve both dermatological and cardiovascular health in this patient population.</p>\",\"PeriodicalId\":10832,\"journal\":{\"name\":\"Current Cardiology Reviews\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Cardiology Reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/011573403X412277250911072530\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Cardiology Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/011573403X412277250911072530","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
The Heart of Psoriasis: Cardiovascular Alterations and Common Inflammatory Mechanisms.
Introduction: This mini-review aims to investigate the shared pathophysiological mechanisms linking psoriasis to cardiovascular disease (CVD), with a particular emphasis on electrocardiographic and echocardiographic alterations in individuals affected by psoriasis.
Methods: A comprehensive search of PubMed and Google Scholar was conducted for studies published between January 1980 and June 2025. The search included clinical trials, observational studies, reviews, and meta-analyses.
Results: The pathogenesis of psoriasis shares several key features with CVD, particularly systemic inflammation and endothelial dysfunction. Psoriasis patients frequently exhibit electrocardiographic abnormalities, such as arrhythmias, including atrial fibrillation (AF), and structural heart changes, such as left ventricular diastolic dysfunction. These cardiovascular changes are often observed even in the absence of clinically evident heart disease.
Discussion: Psoriasis significantly contributes to cardiovascular risk, even in patients without manifest CVD. Chronic inflammation, endothelial dysfunction, and metabolic disturbances are key factors contributing to the increased cardiovascular risk observed in these individuals. Furthermore, the presence of psoriatic arthritis may exacerbate these associations, highlighting the multifaceted nature of the disease.
Conclusion: Early detection and management of cardiovascular alterations in patients with psoriasis are essential for mitigating their long-term cardiovascular burden. Targeting shared inflammatory pathways holds promise as a therapeutic approach to improve both dermatological and cardiovascular health in this patient population.
期刊介绍:
Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.