Mariana Araiza-Guzmán, Bricia M Gutiérrez-Zepeda, Ana M Saldaña-Cruz, Ingrid B Montoya-Delgado, Diana Rubio-Delgado, Pablo Benítez-Villa, Diana M Hernández-Corona, Adrian Daneri-Navarro, Alicia Del Toro-Arreola, Jazmin Márquez-Pedroza, Antonio Quintero-Ramos, Betsabé Contreras-Haro
{"title":"墨西哥西部妇女TP53 IVS3 16bp变异与乳腺癌风险：一项病例对照研究","authors":"Mariana Araiza-Guzmán, Bricia M Gutiérrez-Zepeda, Ana M Saldaña-Cruz, Ingrid B Montoya-Delgado, Diana Rubio-Delgado, Pablo Benítez-Villa, Diana M Hernández-Corona, Adrian Daneri-Navarro, Alicia Del Toro-Arreola, Jazmin Márquez-Pedroza, Antonio Quintero-Ramos, Betsabé Contreras-Haro","doi":"10.3390/cimb47090744","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Mutations in the <i>TP53</i> gene can alter its tumor suppressor functions, thereby promoting oncogenic activity. The <i>TP53</i> IVS3 16 bp genetic variant overlaps with nucleotide sequences that can alter regulatory structures, potentially affecting its function. The aim of the present study was to evaluate the association between <i>TP53</i> IVS3 16 bp genetic variant and the risk of breast cancer (BC) in women from western Mexico.</p><p><strong>Methods: </strong>The study included 220 women diagnosed with BC and 198 cancer-free controls. Clinical and demographic data were collected through structured questionnaires and verified with medical records. Genotyping of the <i>TP53</i> IVS3 16 bp genetic variant was performed using polymerase chain reaction (PCR) and visualized on 6% polyacrylamide gels.</p><p><strong>Results: </strong>Compared to controls, women with BC more frequently reported a family history of the disease and menopausal status (<i>p</i> < 0.05). Genotypic analysis revealed that carriers of the D/I genotype and the combined D/I + I/I genotypes were associated with a reduced risk of BC in codominant (OR = 0.53; 95% CI 0.32-0.88) and dominant (OR = 0.57; 95% CI 0.35-0.93) models.</p><p><strong>Conclusions: </strong>The D/I and D/I + I/I genotypes in codominant and dominant models showed a lower risk against BC. More studies are needed to confirm these findings.</p>","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469232/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>TP53</i> IVS3 16 bp Variant and Breast Cancer Risk in Western Mexican Women: A Case-Control Study.\",\"authors\":\"Mariana Araiza-Guzmán, Bricia M Gutiérrez-Zepeda, Ana M Saldaña-Cruz, Ingrid B Montoya-Delgado, Diana Rubio-Delgado, Pablo Benítez-Villa, Diana M Hernández-Corona, Adrian Daneri-Navarro, Alicia Del Toro-Arreola, Jazmin Márquez-Pedroza, Antonio Quintero-Ramos, Betsabé Contreras-Haro\",\"doi\":\"10.3390/cimb47090744\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Mutations in the <i>TP53</i> gene can alter its tumor suppressor functions, thereby promoting oncogenic activity. The <i>TP53</i> IVS3 16 bp genetic variant overlaps with nucleotide sequences that can alter regulatory structures, potentially affecting its function. The aim of the present study was to evaluate the association between <i>TP53</i> IVS3 16 bp genetic variant and the risk of breast cancer (BC) in women from western Mexico.</p><p><strong>Methods: </strong>The study included 220 women diagnosed with BC and 198 cancer-free controls. Clinical and demographic data were collected through structured questionnaires and verified with medical records. Genotyping of the <i>TP53</i> IVS3 16 bp genetic variant was performed using polymerase chain reaction (PCR) and visualized on 6% polyacrylamide gels.</p><p><strong>Results: </strong>Compared to controls, women with BC more frequently reported a family history of the disease and menopausal status (<i>p</i> < 0.05). Genotypic analysis revealed that carriers of the D/I genotype and the combined D/I + I/I genotypes were associated with a reduced risk of BC in codominant (OR = 0.53; 95% CI 0.32-0.88) and dominant (OR = 0.57; 95% CI 0.35-0.93) models.</p><p><strong>Conclusions: </strong>The D/I and D/I + I/I genotypes in codominant and dominant models showed a lower risk against BC. More studies are needed to confirm these findings.</p>\",\"PeriodicalId\":10839,\"journal\":{\"name\":\"Current Issues in Molecular Biology\",\"volume\":\"47 9\",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469232/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Issues in Molecular Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3390/cimb47090744\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Issues in Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3390/cimb47090744","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
TP53 IVS3 16 bp Variant and Breast Cancer Risk in Western Mexican Women: A Case-Control Study.
Background: Mutations in the TP53 gene can alter its tumor suppressor functions, thereby promoting oncogenic activity. The TP53 IVS3 16 bp genetic variant overlaps with nucleotide sequences that can alter regulatory structures, potentially affecting its function. The aim of the present study was to evaluate the association between TP53 IVS3 16 bp genetic variant and the risk of breast cancer (BC) in women from western Mexico.
Methods: The study included 220 women diagnosed with BC and 198 cancer-free controls. Clinical and demographic data were collected through structured questionnaires and verified with medical records. Genotyping of the TP53 IVS3 16 bp genetic variant was performed using polymerase chain reaction (PCR) and visualized on 6% polyacrylamide gels.
Results: Compared to controls, women with BC more frequently reported a family history of the disease and menopausal status (p < 0.05). Genotypic analysis revealed that carriers of the D/I genotype and the combined D/I + I/I genotypes were associated with a reduced risk of BC in codominant (OR = 0.53; 95% CI 0.32-0.88) and dominant (OR = 0.57; 95% CI 0.35-0.93) models.
Conclusions: The D/I and D/I + I/I genotypes in codominant and dominant models showed a lower risk against BC. More studies are needed to confirm these findings.
期刊介绍：
Current Issues in Molecular Biology (CIMB) is a peer-reviewed journal publishing review articles and minireviews in all areas of molecular biology and microbiology. Submitted articles are subject to an Article Processing Charge (APC) and are open access immediately upon publication. All manuscripts undergo a peer-review process.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
